The abrupt development of adult-like grid cell firing in the medial entorhinal cortex.

Frontiers in Neural Circuits
Thomas J WillsFrancesca Cacucci

Abstract

Understanding the development of the neural circuits subserving specific cognitive functions such as navigation remains a central problem in neuroscience. Here, we characterize the development of grid cells in the medial entorhinal cortex, which, by nature of their regularly spaced firing fields, are thought to provide a distance metric to the hippocampal neural representation of space. Grid cells emerge at the time of weaning in the rat, at around 3 weeks of age. We investigated whether grid cells in young rats are functionally equivalent to those observed in the adult as soon as they appear, or if instead they follow a gradual developmental trajectory. We find that, from the very youngest ages at which reproducible grid firing is observed (postnatal day 19): grid cells display adult-like firing fields that tessellate to form a coherent map of the local environment; that this map is universal, maintaining its internal structure across different environments; and that grid cells in young rats, as in adults, also encode a representation of direction and speed. To further investigate the developmental processes leading up to the appearance of grid cells, we present data from individual medial entorhinal cortex cells recorded acro...Continue Reading

Citations

Apr 20, 2014·PLoS Computational Biology·Bailu SiMisha Tsodyks
Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Chen SunSusumu Tonegawa
Mar 20, 2015·Hippocampus·Michael E Hasselmo, Chantal E Stern
Feb 1, 2014·Developmental Cognitive Neuroscience·Sinéad L Mullally, Eleanor A Maguire
Feb 5, 2014·Current Opinion in Neurobiology·Thomas J Wills, Francesca Cacucci
Jul 16, 2015·Nature·Emilio KropffEdvard I Moser
Jun 19, 2013·NeuroImage·Michael E Hasselmo, Chantal E Stern
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Apr 21, 2016·The Journal of Physiology·Florian RaudiesMichael E Hasselmo
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Aug 9, 2016·Current Biology : CB·Guifen ChenThomas Joseph Wills
Sep 30, 2016·Journal of Physiology, Paris·Holger DannenbergMichael E Hasselmo
Dec 13, 2016·Wiley Interdisciplinary Reviews. Cognitive Science·Hui Min TanFrancesca Cacucci
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Feb 15, 2018·Journal of Neurophysiology·James R HinmanMichael E Hasselmo
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas J WillsFrancesca Cacucci
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Apr 2, 2019·Frontiers in Systems Neuroscience·Nina BerggaardJohannes J L van der Want
Dec 10, 2020·Brain and Neuroscience Advances·Andrew S AlexanderMichael E Hasselmo

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