The abscopal effect associated with a systemic anti-melanoma immune response.

International Journal of Radiation Oncology, Biology, Physics
Emily F StamellIsaac Brownell

Abstract

The clearance of nonirradiated tumors after localized radiation therapy is known as the abscopal effect. Activation of an antitumor immune response has been proposed as a mechanism for the abscopal effect. Here we report a patient with metastatic melanoma who received palliative radiation to his primary tumor with subsequent clearance of all his nonirradiated in-transit metastases. Anti-MAGEA3 antibodies were found upon serological testing, demonstrating an association between the abscopal effect and a systemic antitumor immune response. A brain recurrence was then treated with a combination of stereotactic radiosurgery and immunotherapy with ipilimumab. The patient experienced a complete remission that included resolution of nodal metastases, with a concomitant increase in MAGEA3 titers and a new response to the cancer antigen PASD1. This case supports the immune hypothesis for the abscopal effect, and illustrates the potential of combining radiotherapy and immunotherapy in the treatment of melanoma.

References

Oct 1, 1975·The British Journal of Radiology·D P Kingsley
May 1, 1953·The British Journal of Radiology·R H MOLE
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Sandra DemariaSilvia C Formenti
Sep 13, 2006·The British Journal of Dermatology·S F Rajpar, J R Marsden
Oct 22, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·A AboodD A L Watt
Jan 30, 2009·Journal of the National Cancer Institute·Charlie Schmidt

❮ Previous
Next ❯

Citations

Mar 19, 2013·Current Treatment Options in Oncology·Sarah NicholasMichael Lim
Aug 13, 2013·Current Oncology Reports·David B PageJedd D Wolchok
Jan 28, 2014·The Lancet. Respiratory Medicine·Eric Tartour, Laurence Zitvogel
Mar 29, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S F SlovinT M Beer
Jul 19, 2013·The Journal of Clinical Investigation·Anusha KalbasiNeha Vapiwala
Jan 3, 2014·Case Reports in Oncological Medicine·Jacob RuzevickMichael Lim
Feb 27, 2014·Nature Reviews. Clinical Oncology·Taofeek K OwonikokoJeffrey J Olson
Mar 13, 2014·Seminars in Immunology·Qing ChangJacqueline Bromberg
Jun 3, 2014·Journal of Translational Medicine·Paolo A Ascierto, Francesco M Marincola
Dec 17, 2014·Seminars in Oncology·Susan M Hiniker, Susan J Knox
Dec 3, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·R SunJ Thariat
Oct 29, 2013·FEBS Letters·Chrisann Kyi, Michael A Postow
Feb 3, 2016·Critical Reviews in Oncology/hematology·Magali FortUNKNOWN TRONE (Transatlantic Radiation Oncology NEtwork)
Jul 1, 2015·Redox Biology·Gina MandaKemal Sami Korkmaz
Nov 20, 2015·Current Problems in Cancer·Yazan AbuodehSungjune Kim
Sep 21, 2013·Cancer Letters·Pedro Carlos LaraJosé Mariano Ruiz de Almodóvar
Jul 8, 2015·Vaccine·Claire Vanpouille-BoxSandra Demaria
Mar 10, 2016·Nature Reviews. Clinical Oncology·Michael B BernsteinJoe Y Chang
Jul 12, 2016·Current Oral Health Reports·Rebecca C Hoesli, Jeffrey S Moyer
Mar 17, 2015·Seminars in Radiation Oncology·Sue S YomDavid Raben
Jan 10, 2014·Cancer Medicine·Ann W SilkChristopher D Lao
Nov 29, 2013·Journal of Surgical Oncology·Gerald B Fogarty, Angela Hong
Oct 18, 2015·Journal of the National Cancer Institute·Jaap D ZindlerPhilippe Lambin
Sep 3, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·N H RekersP Lambin
Aug 28, 2015·Immunotherapy·Steven N SeyedinJames W Welsh
Mar 26, 2014·International Journal of Radiation Oncology, Biology, Physics·Matthew WitekAdam E Snook
Mar 26, 2014·International Journal of Radiation Oncology, Biology, Physics·Christopher A Barker, Michael A Postow
Aug 12, 2015·Future Oncology·Anna S Berghoff, Matthias Preusser
Apr 22, 2015·Cancer Letters·Gerard G HannaKevin M Prise
Dec 8, 2014·Seminars in Radiation Oncology·Encouse B Golden, Lionel Apetoh
Dec 8, 2014·Seminars in Radiation Oncology·Aurelien MarabelleHolbrook Kohrt
Dec 8, 2014·Seminars in Radiation Oncology·Karsten A PilonesSandra Demaria
Jul 1, 2015·Nature Reviews. Clinical Oncology·Dörthe Schaue, William H McBride
Jun 25, 2015·Nature Reviews. Cancer·Holly E BarkerKevin J Harrington
Apr 16, 2015·Cancer Treatment Reviews·Kobe ReyndersDirk De Ruysscher
Mar 11, 2015·International Journal of Radiation Oncology, Biology, Physics·Ana P KiessKathryn Beal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.