PMID: 59011Jun 26, 1976

The absence of B-cell antigen B2 from leukaemia cells and lymphoblastoid cell lines

R BillingP Peterson


60 leukaemia patients with acute mylogenous leukaemia, chronic myelocytic leukaemia, acute lymphatic leukaemia, and chronic lymphocytic leukaemia were tested for five specificities of the new B-lymphocyte alloantigenic system. Two specificities of the first B-cell locus were significantly lower in frequency than in B lymphocytes from 105 controls. B-cell group 1 was found in 18% of leukaemia patients vs. 48% of controls (p less than 0.025) and B-cell group 2 was found in 0% of leukaemia patients vs 23% of controls (p less than 0.025). Group 2 was also absent in 37 cultured lymphoblastoid lines. It is suggested that resistance to B-cell leukaemia and to Epstein-Barr virus transformation in vitro may be linked to a B-lymphocyte specificity on the first B-lymphocyte locus.

Related Concepts

Immune Adherence Reaction
Immunoglobulin Allotypes
Lymphoid Leukemia
Leukemia, Monocytic, Chronic
Genetic Linkage Analysis
Acute Myeloid Leukemia, M1

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