PMID: 29020454Oct 12, 2017Paper

The absence of brain-specific link protein Bral2 in perineuronal nets hampers auditory temporal resolution and neural adaptation in mice

Physiological Research
J PopelářJ Syka

Abstract

Brain-specific link protein Bral2 represents a substantial component of perineuronal nets (PNNs) enwrapping neurons in the central nervous system. To elucidate the role of Bral2 in auditory signal processing, the hearing function in knockout Bral2(-/-) (KO) mice was investigated using behavioral and electrophysiological methods and compared with wild type Bral2(+/+) (WT) mice. The amplitudes of the acoustic startle reflex (ASR) and the efficiency of the prepulse inhibition of ASR (PPI of ASR), produced by prepulse noise stimulus or gap in continuous noise, was similar in 2-week-old WT and KO mice. Over the 2-month postnatal period the increase of ASR amplitudes was significantly more evident in WT mice than in KO mice. The efficiency of the PPI of ASR significantly increased in the 2-month postnatal period in WT mice, whereas in KO mice the PPI efficiency did not change. Hearing thresholds in 2-month-old WT mice, based on the auditory brainstem response (ABR) recordings, were significantly lower at high frequencies than in KO mice. However, amplitudes and peak latencies of individual waves of click-evoked ABR did not differ significantly between WT and KO mice. Temporal resolution and neural adaptation were significantly better...Continue Reading

References

Mar 1, 1987·Brain Research·B J BlatchleyJ R Coleman
Jun 1, 1971·Journal of Comparative and Physiological Psychology·J R Ison, G R Hammond
May 1, 1983·The Journal of the Acoustical Society of America·J S Young, L D Fechter
Nov 12, 1993·Neuroscience Letters·M R Celio, R Chiquet-Ehrismann
Apr 14, 1997·The Journal of Comparative Neurology·D I LurieE W Rubel
Jan 9, 1999·Trends in Neurosciences·M R CelioL Vitellaro-Zuccarello
Jul 22, 1999·Annals of the New York Academy of Sciences·B RudyE Vega-Saenz de Miera
Aug 27, 1999·Progress in Neurobiology·M Koch
Nov 15, 2000·The Journal of Comparative Neurology·G BrücknerM Schachner
Jun 5, 2003·Journal of the Association for Research in Otolaryngology : JARO·James R Ison, Paul D Allen
Apr 6, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Uwe RauchGunnel Roos
Jul 13, 2004·Experimental Neurology·Markus MorawskiThomas Arendt
Oct 7, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Hiroko OgawaYoshifumi Ninomiya
Dec 24, 2005·The Journal of Comparative Neurology·Daniela CarulliJames W Fawcett
May 18, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paulette A McRaeRussell T Matthews
Sep 5, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Davide VigettiAndrea Moriondo
Jul 31, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mandy SonntagRudolf Rübsamen
Feb 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoko BekkuToshitaka Oohashi
Apr 28, 2012·The International Journal of Biochemistry & Cell Biology·Renato Frischknecht, Constanze I Seidenbecher
Sep 18, 2012·Experimental Gerontology·Natalia RybalkoJosef Syka
Aug 15, 2014·Frontiers in Neuroscience·Ricardo Gómez-NietoDolores E López
Jan 13, 2015·Hearing Research·Mandy SonntagMarkus Morawski
Mar 10, 2015·Behavioural Brain Research·Natalia RybalkoJosef Syka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.