The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city.

Reproductive Toxicology
Shiqi ZhangYonghuai Li

Abstract

Due to the cellular entry of the novel coronavirus (SARS-CoV-2) modulated by angiotensin converting enzyme 2 (ACE2), the ACE2 bearing prostate is therefore hypothesized as a susceptible organ to COVID-19. To delineate whether the pathogenic SARS-CoV-2 of the coronavirus disease (COVID-19) could be detected in the expressed prostatic secretion (EPS), a total of ten male patients with confirmed COVID-19 were recruited. All patients were stratified into two groups: one group with positive nasopharyngeal swabbing SARS-CoV-2 within 3 days of the EPS taken day (PNS group, n = 3) and the other group with previously positive nasopharyngeal swabbing SARS-CoV-2 but turned negative before the taken day (PNNS group, n = 7). The COVID-19 patients showed elevated inflammatory indictors, i.e. C-reaction protein (3.28 (1.14, 33.33) mg/L), erythrocyte sedimentation rate (22.50 (8.00, 78.50) mm/h), and interleukin-6 (6.49 (4.96, 21.09) pg/ml). Serum IgM against SARS-CoV-2 was only positive in the PNS group, whereas serum IgG was positive for all patients. Furthermore, our data showed for the first time that none of the COVID-19 patients had positive SARS-CoV-2 RNA in EPS. To this end, this study found the negativity of SARS-CoV-2 in EPS and poss...Continue Reading

Citations

Aug 28, 2020·Future Microbiology·Elaheh Kordzadeh-KermaniIman Karimzadeh
Jan 12, 2021·Andrology·Yangcheng YaoYufeng Li
Jan 30, 2021·Fertility and Sterility·Darshan P PatelJames M Hotaling
Nov 30, 2020·Reproductive Toxicology·Temidayo S OmolaoyeStefan S du Plessis
Jun 15, 2021·Frontiers in Endocrinology·Yanfei HeXuejiao Chen
Aug 13, 2021·Human Fertility : Journal of the British Fertility Society·Marziye Farsimadan, Mohammad Motamedifar
Aug 18, 2021·BJU International·Daniel E NassauRanjith Ramasamy
Nov 24, 2020·Urologia Internationalis·Peng JinJayoung Kim
May 19, 2021·Journal of Molecular Cell Biology·Ming YangJie Qiao

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