PMID: 6163136Jan 24, 1981Paper

The absence of introns within a human fibroblast interferon gene

Nucleic Acids Research
M HoughtonN H Carey

Abstract

Experiments in which immobilised restriction fragments of genomic DNA were hybridised with a cloned human fibroblast interferon cDNA indicate that the homologous chromosomal genes exist in only one basic arrangement. This is in marked contrast to recent studies by Nagata et al. (1) showing that there are at least eight gene arrangements for human leukocyte interferon. Having isolated a chromosomal human fibroblast interferon gene from a gene bank, we conclude from nucleotide sequencing studies that there is a complete absence of introns within the RNA-coding region. In view of a similar observation recently made for a human leukocyte interferon gene (1), it would appear as if interferon genes in general are unlike the vast majority of eukaryote genes in this respect.

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C J Lai, G Khoury
Dec 1, 1979·Cell·D H Hamer, P Leder
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A M Maxam, W Gilbert
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R L CavalieriS Pestka
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J L ManleyM L Gefter
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M RubinsteinS Pestka
Apr 20, 1979·Science·F Crick
Feb 9, 1978·Nature·W Gilbert
Feb 11, 1976·Proceedings of the National Academy of Sciences of the United States of America·E Knight
Jun 1, 1980·Gene·T TaniguchiM Muramatsu
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S SteinS Pestka
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A JungG Schütz
Jan 10, 1980·Nature·A J Twigg, D Sherratt
Sep 19, 1980·Science·P LederC Talkington

❮ Previous
Next ❯

Citations

Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·N B Raj, P M Pitha
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P M PithaG S Hayward
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K ZinnT Maniatis
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D Canaani, P Berg
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P B SehgalM Inouye
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·N B Raj, P M Pitha
Jan 1, 1984·Biotechnology & Genetic Engineering Reviews·M D Edge, R Camble
Sep 1, 1982·The Journal of Experimental Medicine·A D SagarF H Ruddle
Mar 1, 1983·The Journal of Experimental Medicine·S L NaylorP W Gray
Jan 1, 1982·Journal of Interferon Research·E Dworkin-RastlP Swetly
Jan 1, 1983·Journal of Interferon Research·K G McCullaghM Houghton
Aug 1, 1994·Journal of Interferon Research·G Allen, M O Diaz
Feb 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G Allen, M O Diaz
Jun 25, 1982·Nucleic Acids Research·R DerynckD V Goeddel
Feb 11, 1983·Nucleic Acids Research·G D ShawC Weissmann
Jan 25, 1984·Nucleic Acids Research·R DijkemaH Schellekens
Feb 11, 1985·Nucleic Acids Research·E C ZwarthoffJ Trapman
Jan 24, 1986·Nucleic Acids Research·F CostanzoR Cortese
Apr 15, 1985·International Journal of Cancer. Journal International Du Cancer·R A Hekman, J Trapman
Aug 20, 1981·Nature·M D EdgeA F Markham
Aug 26, 1982·Nature·P W Gray, D V Goeddel
Sep 30, 1982·Biochimica Et Biophysica Acta·P B Sehgal
May 1, 1982·Molecular and Cellular Biology·P M PithaF H Ruddle
Feb 1, 1983·Molecular and Cellular Biology·S Mayrand, T Pederson
Mar 23, 1984·Science·A D SagarF H Ruddle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.