PMID: 9183023May 1, 1997Paper

The absence of the mitochondrial ATP synthase delta subunit promotes a slow growth phenotype of rho- yeast cells by a lack of assembly of the catalytic sector F1

European Journal of Biochemistry
M F Giraud, J Velours

Abstract

In the yeast Saccharomyces cerevisiae, inactivation of the gene encoding the delta subunit of the ATP synthase led to a lack of assembly of the catalytic sector. In addition a slow-growth phenotype was observed on fermentable medium. This alteration appears in strains lacking intact mitochondrial DNA and showing a defect in the assembly of the catalytic sector, such as the yeast strain inactivated in the gene encoding the epsilon subunit. In rho mitochondria having an intact F1, the ion movement resulting from the exchange of ADP formed in the organelle and ATP entering the mitochondrial compartment led to a mitochondrial transmembranous potential delta psi that was sensitive to carboxyactractyloside. This ion movement was dramatically decreased in rho mitochondria lacking the delta subunit and thus the F1 sector, whereas a cell devoid of delta subunit and complemented with a plasmid harboring the ATPdelta gene displayed an assembled F1, a normal generation time and a fully restored mitochondrial potential. This result could be linked to the involvement of the membrane potential delta psi which is indispensible for mitochondrial biogenesis.

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Citations

Jun 29, 2005·Current Genetics·Eugene G RikhvanovVictor K Voinikov
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stéphane Duvezin-CaubetJean-Paul di Rago
Apr 2, 2011·The Journal of Biological Chemistry·François GodardJean-Paul di Rago
Oct 11, 2011·The Journal of Biological Chemistry·Praveen Balabaskaran NinaAkhil B Vaidya
Nov 26, 2004·Molecular Biology of the Cell·Quan ZhongMiriam L Greenberg
Nov 4, 2005·Molecular Biology of the Cell·Cory D DunnRobert E Jensen
Oct 10, 2008·Molecular Biology of the Cell·Cory D DunnRobert E Jensen
Feb 2, 2002·The EMBO Journal·Patrick PaumardJean Velours
Dec 7, 2010·Applied and Environmental Microbiology·Suvarna Dasari, Ralf Kölling
Dec 13, 2005·Eukaryotic Cell·Christopher P Smith, Peter E Thorsness
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·V Contamine, M Picard
Aug 24, 2013·Oxidative Medicine and Cellular Longevity·Yaxin Liu, Xin Jie Chen
Sep 17, 2005·Progress in Nucleic Acid Research and Molecular Biology·Sharon H Ackerman, Alexander Tzagoloff
Jun 24, 2014·Molecular Systems Biology·Atsushi FukuohHoward T Jacobs
Aug 16, 2014·The Journal of Biological Chemistry·Carola S MehnertMartin van der Laan
Jan 10, 2019·FEMS Yeast Research·Cullen HorstmannKyoungtae Kim
Sep 26, 2007·The Journal of Cell Biology·David K HwangCarla M Koehler
Jun 26, 2015·FEMS Microbiology Reviews·Adrianna SkonecznaMarek Skoneczny
Jun 22, 2012·Molecular Biology Reports·Kitti WuthisathidTimothy W Flegel
Feb 22, 2012·Acta Biochimica Et Biophysica Sinica·Wei XiongDeyong Tan
Dec 15, 2020·Biochemical and Biophysical Research Communications·Pierre MounkoroBrigitte Meunier
May 17, 2006·Biochimica Et Biophysica Acta·Boris A FenioukMasasuke Yoshida

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