PMID: 7090844Mar 1, 1982Paper

The absorption and excretion of methyldopa ingested concomitantly with amino acids or food rich in protein

Acta Pharmacologica Et Toxicologica
O StenbaekT Hansen

Abstract

Absorption and urinary excretion of 2-14C-L-alpha-methyldopa (alpha MD) were investigated in 5 healthy human volunteers. The drug was administered alone, with a mixture of amino acids and with a meal consisting of roast beef. The radioactivity in plasma and urine was not decreased significantly by either treatment, and it was concluded that the overall absorption of the drug was virtually unchanged. The amount of unconjugated alpha MD in plasma and urine, however, was significantly decreased following administration of the drug with roast beef. As the acid labile conjugates of alpha MD were practically unchanged an increased biotransformation to other metabolites owing to the protein rich meal was suggested more probable than competition between alpha MD and amino acids in the specific transport systems.

References

Oct 14, 1977·European Journal of Clinical Pharmacology·O StenbaekT Hansen
Apr 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·E MyhreT Hansen
Apr 14, 1962·Lancet·C T DOLLERY, M HARINGTON
Oct 1, 1963·Circulation·A SJOERDSMAK ENGELMAN

Citations

May 1, 1986·The Journal of Pharmacy and Pharmacology·G L AmidonJ B Dressman
Mar 1, 1996·The Journal of Pharmacy and Pharmacology·H P WangH S Kuo
Nov 1, 1986·The Journal of Pharmacy and Pharmacology·A E MerfeldG L Admidon
Jun 24, 1985·The Medical Journal of Australia·G M PetersonK S Millingen

Related Concepts

Metabolic Biotransformation
Diet
Dietary Proteins
Intestinal Absorption
Sembrina

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