PMID: 9174545Apr 1, 1997Paper

The abundant presence of Söderström bodies in cytology smears of fine-needle aspirates contributes to distinguishing high-grade non-Hodgkin's lymphoma from carcinoma and sarcoma

Annals of Hematology
M BangerterT Binder

Abstract

Söderström bodies, also termed lymphoglandular bodies (LGB) and detectable in fine-needle aspiration cytology smears, have long been accepted as indicative of lymphoid tissues. To investigate the validity of this association, we examined 588 cytologic smears from high-grade non-Hodgkin's lymphoma (NHL), carcinoma, and sarcoma. Slides with lymphocytes in the vicinity of carcinoma and sarcoma cells had been excluded. Two independent observers scored smears to number, size, color, form, and smear background of the LGB. In 68 of 359 (19%) nonlymphoid malignancies rare (defined as < 1 LGB per high-power field) or occasional LGB (defined as 1-20 LGB per high-power field) were detectable. Half of these tumors consisted of melanomas, small cell lung carcinomas, and teratomas; the other half encompassed undifferentiated sarcomas. However, none of the smears obtained from carcinoma or sarcoma tissue had abundant LGB (defined as > 20 LGB per high-power field). When number of LGB was estimated to be abundant, the sensitivity for diagnosing a lymphoma was 54%; however, specificity was 100%. The difference in showing LGB between high-grade NHL and carcinoma/sarcoma was highly significant (p = 0.0001). The presence of abundant LGB in cytologi...Continue Reading

Citations

Apr 4, 2001·Diagnostic Cytopathology·R C SternL J Layfield
Jun 8, 2001·Diagnostic Cytopathology·R SaadJ F Silverman
Jun 14, 2012·Pathology Research International·Joerg Schwock, William R Geddie
Dec 25, 2003·Leukemia & Lymphoma·D TamiolakisN Papadopoulos
Nov 19, 2010·Prosthetics and Orthotics International·Jan Andrysek
Mar 15, 2020·Cytopathology : Official Journal of the British Society for Clinical Cytology·Takahiko SakumaYusuke Matsumoto
Feb 16, 2012·Diagnostic Cytopathology·Negar AzarpiraAlireza Rasekhi
May 7, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·U HandaH Mohan

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