The AC/AG Diplotype for the 118A>G and IVS2 + 691G>C Polymorphisms of OPRM1 Gene is Associated with Sleep Quality Among Opioid-Dependent Patients on Methadone Maintenance Therapy

Pain and Therapy
Zalina ZahariRusli Ismail

Abstract

Methadone is a full agonist of the opioid receptor mu 1 which is encoded by the OPRM1 gene. Sleep disorders were frequently reported by opioid-dependent patients during methadone maintenance therapy (MMT). It is possible, therefore, that genetic polymorphisms in OPRM1 influence sleep quality among patients on MMT. This study investigated the association of OPRM1 polymorphisms with sleep quality among opioid-dependent patients on MMT. The sleep quality of 165 male opioid-dependent patients receiving MMT was evaluated using the Pittsburgh Sleep Quality Index (PSQI). DNA was extracted from whole blood and subjected to polymerase chain reaction (PCR) genotyping. Patients with IVS2 + 691 CC genotype had higher PSQI scores [mean (SD) = 5.73 (2.89)] compared to those without the IVS2 + 691 CC genotype (IVS2 + 691 GG/GC genotype) [4.92 (2.31)], but the difference did not reach statistical significance (p = 0.081). Patients with combined 118 AA genotype and IVS2 + 691 GC genotype (AC/AG diplotype) had significantly lower PSQI scores [mean (SD) = 4.25 (2.27)] compared to those without the diplotype [5.68 (2.77)] (p = 0.018). Our study indicates that the AC/AG diplotype for the 118A>G and IVS2 + 691G>C polymorphisms of OPRM1 gene is assoc...Continue Reading

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Citations

Mar 24, 2018·The American Journal on Addictions·Dian-Jeng LiCheng-Fang Yen
Apr 18, 2020·Journal of Psychoactive Drugs·Agnieszka I ChrobokOliver Pogarell
Nov 24, 2017·Molecular Diagnosis & Therapy·Francina Fonseca, Marta Torrens
Apr 9, 2021·Journal of Pharmacy & Bioallied Sciences·Zalina ZahariRusli Ismail

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

Golden Helix SNP and Variation Suite 7 ( SVS
/ Win
SPSS

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