PMID: 7384753Jan 1, 1980

The accessory cell effects of liver macrophages in concanavalin A stimulation of rat spleen lymphocytes

Scandinavian Journal of Immunology
A C Munthe-Kaas

Abstract

Liver and peritoneal macrophages under similar test conditions behaved in an identical manner with regard to accessory cell effects in the lymphocyte response to concanavalin A. When present in low concentrations (less than or equal to 3.3%) they stimulate lymphocytes, and when present in high concentrations (greater than or equal to 10%) they inhibit lymphocyte proliferation. These two effects are, however, mediated through totally different mechanisms. Stimulation was an early effect, required viable cells, was not affected by enzymatic treatment of macrophages, and was similar to the effect of 2-mercaptoethanol, allogeneic macrophages, and even non-macrophages. Inhibition occurred at a larger stage of lymphocyte transformation, was sensitive to collagenase and pronase treatment of macrophages, was more specifically due to macrophages, was reduced with allogeneic macrophages, and persisted after freeze-thawing of macrophages. Removal of Fc receptors or related segments of the surface of macrophages greatly reduced their inhibitory capacity, whereas removal of foreign surface receptors apparently had no consequence.

References

Mar 15, 1977·Cellular Immunology·J R OehlerJ Y Djeu
Jan 1, 1979·Cellular Immunology·D T UmetsuG J Thorbecke
Jul 19, 1979·Nature·E L Larsson, A Coutinho
Mar 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·P TanapetJ D Broome
Sep 1, 1978·Experimental Cell Research·K H StenzelA Novogrodsky
Mar 1, 1976·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C K Nair, D S Pradhan
Jan 1, 1975·The Journal of Experimental Medicine·A C Munthe-KaasR Seljelid
Jul 1, 1975·Cellular Immunology·H G OpitzH D Flad
Jan 1, 1972·Advances in Immunology·E R Unanue
Jul 1, 1970·The Journal of Experimental Medicine·R C Seeger, J J Oppenheim

Citations

Jul 1, 1982·The Journal of Experimental Medicine·W E KlinkertW E Bowers
Dec 1, 1987·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·B JohneB Mørland

Related Concepts

Concanavalin A
Hepatic Macrophage
Liver
Lymphocyte Activation
Lymphoid Cells
Macrophage
2-Mercaptoethanol
Phagocytosis
Fc Receptor
Spleen

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