PMID: 20629332Jul 16, 2010Paper

The accuracy of combining aldosterone to renin ratio and low renin level in diagnosing primary aldosteronism

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Fang LiTie-Yun Zhao

Abstract

To evaluate the accuracy of combing serum aldosterone to plasma rennin ratio (ARR) and low renin level in diagnosing primary aldosteronism (PA). The ratio of serum aldosterone to plasma renin was determined in 100 patients with PA and 61 patients with primary hypertension. The optimum cut-point of ARR was determined by the Receiver Operating Characteristic (ROC). The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and Youden index of the ARR at the optimum cut-off point were calculated in a separate test. The sensitivity and specificity of combining ARR and low renin level or high aldosterone level in diagnosing PA were determined. The supine ROC area under the curve (AUC1) was 0.991. The erect ROC area under the curve (AUC2) was 0.988. The AUC1 and AUC2 had no significant difference (P = 0.879). But they were both different significantly from with the area under the reference line (0.5) (P = 0.000). The optimum cut-off point of supine ARR was 112.06, with 0.96, 0.95, 0.91, 19.59 and 0.04 in sensitivity, specificity, Youden index, positive likelihood ratio and negative likelihood ratio, respectively. Combining ARR and low renin level produced a sensitivity and specificity of 0.422 and 0.998, respe...Continue Reading

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