PMID: 11912118Mar 26, 2002Paper

The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service

Brain : a Journal of Neurology
Andrew J HughesAndrew J Lees

Abstract

We have reviewed the clinical and pathological diagnoses of 143 cases of parkinsonism seen by neurologists associated with the movement disorders service at The National Hospital for Neurology and Neurosurgery in London who came to neuropathological examination at the United Kingdom Parkinson's Disease Society Brain Research Centre, over a 10-year period between 1990 and the end of 1999. Seventy-three (47 male, 26 female) cases were diagnosed as having idiopathic Parkinson's disease (IPD) and 70 (42 male, 28 female) as having another parkinsonian syndrome. The positive predictive value of the clinical diagnosis for the whole group was 85.3%, with 122 cases correctly clinically diagnosed. The positive predictive value of the clinical diagnosis of IPD was extremely high, at 98.6% (72 out of 73), while for the other parkinsonian syndromes it was 71.4% (50 out of 70). The positive predictive values of a clinical diagnosis of multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) were 85.7 (30 out of 35) and 80% (16 out of 20), respectively. The sensitivity for IPD was 91.1%, due to seven false-negative cases, with 72 of the 79 pathologically established cases being diagnosed in life. For MSA, the sensitivity was 88....Continue Reading

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References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Feb 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·J M FearnleyA J Lees
Aug 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A H RajputA Rajput
Jun 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·W R Gibb, A J Lees
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Feb 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·G K WenningN P Quinn
Aug 1, 1994·Brain : a Journal of Neurology·G K WenningN P Quinn
Oct 1, 1994·Brain : a Journal of Neurology·J O RinneC D Marsden
Jul 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·V M De Bruin, A J Lees
Feb 1, 1993·Archives of Neurology·A J HughesA J Lees
Jan 1, 1996·Acta Neuropathologica·M Jackson, J Lowe
Jan 1, 1996·Acta Neuropathologica·M VernyY Agid
Mar 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·G K WenningN P Quinn
Mar 7, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·G K WenningR K Pearce
May 1, 1999·Journal of the Neurological Sciences·S GilmanG K Wenning
Sep 24, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·H R MorrisN W Wood
Mar 23, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·G K WenningN P Quinn
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·J D O'SullivanA J Lees

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Citations

Jun 20, 2002·American Journal of Industrial Medicine·Christine B Novak, Susan E Mackinnon
Oct 7, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Paul Morrish
Oct 27, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Aideen McInerney-LeoJohn Hardy
Aug 30, 2008·Der Nervenarzt·A StrzelczykW H Oertel
Mar 18, 2006·Experimental Brain Research·A W MichellR A Barker
Mar 26, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Randel L SwansonHoward Hurtig
Feb 1, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Diederick StoffersHenk W Berendse
Oct 18, 2005·European Journal of Nuclear Medicine and Molecular Imaging·S A EshuisP L Jager
Nov 28, 2008·European Journal of Nuclear Medicine and Molecular Imaging·S A EshuisK L Leenders
Jul 2, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Susanna Jakobson MoKatrine Riklund
Mar 3, 2006·Journal of Neurology·Johannes SchwarzAlexander Storch
Dec 18, 2007·Journal of Neurology·Jerzy SlowinskiZbigniew K Wszolek
Sep 20, 2008·Journal of Neurology·Guido AlvesJan Petter Larsen
Jun 12, 2013·Histochemistry and Cell Biology·Claire Lépinoux-Chambaud, Joël Eyer
Jul 6, 2005·Journal of Neural Transmission·G GossrauJ B Lampe
Nov 12, 2010·Journal of Neural Transmission·Edna GrünblattPeter Riederer
Sep 2, 2011·Journal of Neural Transmission·Krzysztof SadowskiAndrzej Friedman
Mar 16, 2013·Journal of Neural Transmission·Roongroj Bhidayasiri, Heinz Reichmann
Mar 30, 2006·Current Treatment Options in Neurology·Daniel Tarsy
Jan 13, 2012·Annals of Nuclear Medicine·Nikolaos PapathanasiouIoannis Datseris
Mar 21, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ken Nakamura
Feb 5, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jose-Alberto PalmaJorge Iriarte
Jul 10, 2003·Lancet Neurology·David J Burn, Andrew J Lees
Dec 12, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Taryn O HallKaren L Edwards
Sep 3, 2009·Nature Reviews. Neurology·Michael Eller, David R Williams
Mar 27, 2013·Nature Reviews. Neurology·Maria José Martí, Eduardo Tolosa
Oct 4, 2012·The Pharmacogenomics Journal·E M Hill-BurnsH Payami
Dec 5, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·W Poewe, G Wenning
Jul 4, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Bala V Manyam, Abhimanyu Kumar
Jun 30, 2010·Brain : a Journal of Neurology·Helen LingAndrew J Lees
Aug 4, 2011·Brain : a Journal of Neurology·Jeffrey L CummingsPaul Kemp
Jul 26, 2013·Brain : a Journal of Neurology·Jeffrey H KordowerRaymond T Bartus

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