The accuracy of frozen section diagnosis of pulmonary nodules: evaluation of inflation method during intraoperative pathology consultation with cryosection

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Xianhua XuGheeyoung Choe

Abstract

Intraoperative frozen section diagnosis (FSD) is a very important pathologic examination that can determine the extent of the subsequent surgical procedure. However, FSD is especially difficult in small pulmonary nodules due to severe architectural distortion during cryosection. This study was undertaken to determine the accuracy of FSD of pulmonary nodules and to evaluate the inflation method during cryosection. We retrospectively reviewed FSD of 229 consecutive pulmonary nodules and evaluated the diagnostic accuracy and efficacy of inflation method during cryosection. Since August 2006, all frozen sections (165, 72.1%) were made after inflation with optimally diluted embedding medium. The FSD were as follows: nonneoplastic lesions (29, 12.7%), benign neoplasms (28, 12.2%), and malignant neoplasms (172, 75.1%). The proportion of the lesions smaller than 2 cm was 60.3% (138 of 229). The frozen section quality of lung tissue was excellent after inflation with diluted embedding medium. Inflated lung specimens harboring minute lesion displayed distinct gross appearance, which could not be palpated. Histologically, open air spaces and normal parenchymal architectures were well preserved. Minute precancerous foci such as atypical ad...Continue Reading

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Citations

Apr 9, 2013·Journal of Clinical Pathology·Keith M Kerr
Dec 1, 2012·Archives of Pathology & Laboratory Medicine·Ann E Walts, Alberto M Marchevsky
Nov 29, 2013·Archives of Pathology & Laboratory Medicine·Erik ThunnissenMing-Sound Tsao
Apr 1, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hyun Ju LeeJin-Haeng Chung
Jun 30, 2012·Revue des maladies respiratoires·V MoliniéA Balaton
Mar 1, 2010·Surgical Pathology Clinics·Andre L Moreira
May 30, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Humberto E Trejo BittarSanja Dacic
Apr 25, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
Jul 27, 2011·Therapeutic Advances in Medical Oncology·Frances A Shepherd, Gordon Mallarkey
Aug 30, 2014·Archives of Pathology & Laboratory Medicine·Joseph A TworekPeter J Howanitz
Mar 10, 2020·BioMed Research International·Guanghao SunShun Xu
Dec 19, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mincheol ChaeSanghoon Jheon
Nov 18, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yeon Bi HanJin-Haeng Chung
Jul 8, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Zhigang WeiXin Ye
Aug 5, 2010·Analytical Chemistry·Julia BalogZoltan Takats

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