The accuracy of target delineation in laryngeal and hypopharyngeal cancer

Acta Oncologica
Joana Caldas-MagalhaesCornelis P J Raaijmakers

Abstract

To determine the spatial correspondence between the gross tumor volume (GTV) delineated on computer tomography (CT) and the actual tumor on histopathology. Sixteen patients with T3 or T4 laryngeal or hypopharyngeal cancer underwent a CT scan before total laryngectomy. The GTV was delineated on CT by three independent observers and by consensus between the three observers. After surgery, whole-mount hematoxylin-eosin stained (H&E) sections were obtained. One pathologist delineated the tumor in the H&E sections (tumorH&E). The reconstructed specimen was registered to the CT scan in order to compare the GTV to the tumorH&E in three dimensions. The overlap between the GTV and the tumorH&E was calculated and the distance between the volumes was determined. Tumor tissue was delineated in 203 of 516 H&E sections. For 14 patients a detailed analysis could be performed. The GTV volume was on average 1.7 times larger than the volume of the tumorH&E. The mean coverage of the tumorH&E by the consensus GTV was 88%. tumorH&E tissue was found at 1.6 mm to 12.9 mm distance outside the GTV depending on observer and patient. GTVs delineated on CT for laryngeal and hypopharyngeal cancer were 1.7 times larger than the tumor. Complete coverage of t...Continue Reading

References

Nov 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Robert HermansPhilippe Lambin
May 28, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Xavier GeetsVincent Grégoire
May 12, 2009·International Journal of Radiation Oncology, Biology, Physics·Gerda M VerduijnCornelis A T van den Berg
Jul 2, 2011·International Journal of Radiation Oncology, Biology, Physics·Joana Caldas-MagalhaesMarielle E P Philippens
Aug 15, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Dominic A X SchinaglJohannes H A M Kaanders

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Citations

Mar 10, 2016·Current Opinion in Otolaryngology & Head and Neck Surgery·Bénédicte Henriques de Figueiredo, Vincent Grégoire
Nov 18, 2017·Acta Oncologica·Cai GrauJens Overgaard

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