The accurate relationship between spine bone density and bone marrow in humans.

Bone
Xiaoguang ChengGlen M Blake

Abstract

The accuracy of QCT measurements of lumbar spine trabecular volumetric bone mineral density (vBMD) is decreased due to differences in the amount of bone marrow adipose tissue (BMAT). To correct vBMD measurements for differences in marrow composition and investigate the true relationship between vBMD and BMAT. Cross-sectional study. University teaching hospital. Healthy Chinese subjects (233 women, 167 men) aged between 21 and 82 years. vBMD and BMAT were measured using QCT (120 kV) and chemical shift-encoded MRI of the L2-L4 vertebrae. vBMD measurements were standardized to the European Spine Phantom (ESP) and corrected for differences in BMAT. Linear regression was used to analyze BMAT, ESP adjusted vBMD (vBMDESPcorr) and BMAT corrected vBMD (vBMDBMATcorr) against age and corrected vBMD against BMAT. BMAT in the L2-L4 vertebral bodies increased with age in both sexes, with a faster rate of change in women compared with men (0.54%/year vs. 0.27%/year, P < 0.0001). After vBMD measurements were corrected for BMAT there were statistically significant changes in the slope of the regression line with age in both sexes (women: -3.00 ± 0.13 vs. -2.57 ± 0.11 mg/cm3/year, P < 0.0001; men: -1.92 ± 0.15 vs. -1.70 ± 0.14 mg/cm3/year, P < 0...Continue Reading

Citations

Jun 26, 2020·Journal of Magnetic Resonance Imaging : JMRI·Nico SollmannThomas Baum
Sep 30, 2020·Seminars in Musculoskeletal Radiology·James F Griffith
Sep 6, 2020·The Spine Journal : Official Journal of the North American Spine Society·Zach PenningtonDaniel M Sciubba

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