The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue

Gene
C A TaylorA D Shirras

Abstract

Mammalian angiotensin-converting enzyme (ACE) exists as two forms, somatic (sACE), controlling blood pressure via angiotensin II, and testicular (tACE), whose function is unknown. The former has two highly homologous N- and C-terminal Zn2+ metallopeptidase active sites, whereas the latter only has one, which is identical to the C-terminal domain of sACE. We have sequenced 2452 bases of a 3.1-kb mRNA whose predicted translation product shows 40% identity with mammalian testicular ACE, and 48% identity with an already identified Drosophila homologue of ACE (Ance). We have termed this gene Acer (Angiotensin converting enzyme-related). Acer mRNA is found in the developing dorsal vessel (heart) during embryogenesis. Phylogenetic analysis indicates that duplication of an ancestral ACE gene occurred in the lineage leading to the arthropods, independently of the duplication which gave rise to the two domain somatic ACE of mammals.

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Citations

Feb 20, 2003·Developmental Biology·Debra HurstAlan D Shirras
Apr 5, 2002·Trends in Pharmacological Sciences·Anthony J Turner, Nigel M Hooper
Apr 15, 2003·Trends in Cardiovascular Medicine·Gavin Y OuditJosef M Penninger
Dec 12, 2003·Nature Reviews. Drug Discovery·K Ravi AcharyaMario R W Ehlers
Feb 4, 2010·Journal de la Société de biologie·Guillaume Rivière
Dec 7, 2005·BMC Genomics·Susan BurnhamAlan D Shirras
Jul 17, 2014·Journal of Cell Communication and Signaling·Charlotte Harrison, K Ravi Acharya
Jun 21, 2011·European Journal of Cell Biology·Heiko MeyerAchim Paululat
Jan 13, 2006·The FEBS Journal·Richard J BinghamR Elwyn Isaac
Jun 10, 2015·BMC Genomics·Maria Vittoria ModicaMarco Oliverio
Jan 28, 2017·Gene·Hai-Yan YanHideki Kawasaki
May 19, 2004·Insect Biochemistry and Molecular Biology·Nathalie Macours, Korneel Hens
Jun 21, 2002·Nature·Michael A CrackowerJosef M Penninger
Oct 24, 2002·The Journal of Biological Chemistry·Galyna Sidyelyeva, Lloyd D Fricker
Aug 12, 2020·Cellular and Molecular Life Sciences : CMLS·Jie WuXiuhong Yang

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