The acetate recovery factor to correct tracer-derived dietary fat oxidation in humans

American Journal of Physiology. Endocrinology and Metabolism
Audrey BergouignanStéphane Blanc

Abstract

When using (13)C tracer to measure plasma fat oxidation, an acetate recovery factor should be determined in every subject to correct for label sequestration. Less is known regarding the acetate recovery factor for dietary fatty acid oxidation. We compiled data from six studies to investigate the determinants of the dietary acetate recovery factor (dARF) at rest and after physical activity interventions and compared the effects of different methods of dARF calculation on both the fat oxidation and its variability. In healthy lean subjects, dARF was 50.6 +/- 5.4% dose (n = 56) with an interindividual coefficient of variation of 10.6% at rest and 9.2% after physical activity modifications. The physical activity interventions did not impact dARF, and the intraindividual coefficient of variation was 4.6%. No major anthropological or physiological determinants were detected except for resting metabolic rate, which explains 7.4% of the dARF variability. Applying an individual or an average group dARF did not affect the mean and the variability of the derived dietary lipid oxidation at rest or after physical activity interventions. Using a mean dARF for a group leads to over- or underestimation of fat oxidation of less than 10% in indi...Continue Reading

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Citations

Jul 16, 2010·American Journal of Physiology. Endocrinology and Metabolism·Leanne HodsonFredrik Karpe
Oct 25, 2012·Journal of Lipid Research·Christina KoutsariMichael D Jensen
Nov 20, 2008·Diabetes·Audrey BergouignanStéphane Blanc
Feb 12, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Kyla D HuebnerJudy E Anderson
Aug 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Nadia HedhliChristophe Depre
Sep 29, 2015·The Journal of Clinical Endocrinology and Metabolism·Camilla PramfalkLeanne Hodson
Aug 12, 2018·Hormone Molecular Biology and Clinical Investigation·Charlotte J GreenLeanne Hodson
Nov 26, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Gihan NaguibYaron Rotman
Jul 4, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E LefaiC Simon
Apr 20, 2021·American Journal of Physiology. Endocrinology and Metabolism·Émilie MontastierAndré C Carpentier

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