The acid tolerance response of Salmonella typhimurium provides protection against organic acids

Microbiology
H S BaikJohn W Foster

Abstract

Salmonella typhimurium encounters a variety of acid stress situations during pathogenesis and in the natural environment. These include the extreme low pH encountered in the stomach and a less acidic intestinal environment containing large amounts of organic weak acids (volatile fatty acids). The acid tolerance response (ATR) is a complex defence system that can minimize the lethal effects of extreme low pH (pH3). The data presented illustrate that the ATR can also defend against weak acids such as butyric, acetic or propionic acids. Although an acid shock of pH 4.4 induced the ATR, growth in subinhibitory concentrations of weak acids did not. Various mutations shown to affect tolerance to extreme acid conditions (pH 3) were tested for their effects on tolerance to weak acids. An rpoS mutant lacking the alternative sigma factor sigma s failed to protect cells against weak acids as well as extreme acid pH. The fur (ferric uptake regulator) and atp (Mg(2+)-dependent ATPase) mutants defective in extreme acid tolerance showed no defects in their tolerance to weak acids. Curiously, the atbR mutant that exhibits increased tolerance to extreme acid pH proved sensitive to weak acids. Several insertions that rendered cells sensitive to ...Continue Reading

Citations

Jul 29, 2005·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·P RishiS C Ricke
Jan 16, 2002·International Journal of Food Microbiology·T SainzC Eslava
Sep 17, 1999·International Journal of Food Microbiology·S Brul, P Coote
Oct 14, 2009·Foodborne Pathogens and Disease·Andrew D WalesRobert H Davies
Jan 15, 2008·Applied and Environmental Microbiology·Anne N ReidAlain Stintzi
May 2, 2000·Applied and Environmental Microbiology·H L AlakomiI M Helander
Apr 7, 2006·Applied and Environmental Microbiology·Shawn M D BearsonMark A Rasmussen
Nov 18, 2000·Infection and Immunity·D S MerrellA Camilli
Sep 25, 2007·Journal of Bacteriology·Koichi InoueMasayori Inouye
Jan 22, 2013·Journal of Bacteriology·Elise M FontenotCory G Toyota
Apr 9, 2001·Journal of Bacteriology·D S MerrellA Camilli
Jun 5, 2013·Molecular Oral Microbiology·S YonedaH Senpuku
Sep 6, 2005·Research in Microbiology·Nathalie MaroncleChristiane Forestier
Jul 5, 2001·International Journal of Medical Microbiology : IJMM·J P AudiaJ W Foster
Jan 13, 2006·Journal of Molecular Biology·Uhn Soo ChoWenqing Xu
Aug 12, 2016·Pathogens·Franziska WarneboldtChristoph Georg Baums
Jun 26, 2008·Anaerobe·K D DunkleyS C Ricke
Oct 21, 2016·Biotechnology Journal·Carlos H Luna-FloresEsteban Marcellin
Jan 8, 2017·British Journal of Pharmacology·Gareth Hughes, Mark A Webber
Aug 11, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Sonja AxmannIrmengard Strnad
Nov 16, 2017·Nature Communications·Smarajit ChakrabortyLinda J Kenney
Dec 20, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Josephine E Clark-Curtiss, Roy Curtiss
Sep 20, 2015·Applied and Environmental Microbiology·Daniel RyanMrutyunjay Suar
Dec 4, 2013·Microbiology and Molecular Biology Reviews : MMBR·Steven L FoleyJessica Danzeisen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.