PMID: 3214123Jul 1, 1988Paper

The acidification response of normal subjects to ammonium chloride using a 3-day loading test

Annals of Clinical Biochemistry
I D FryJ E Tovey

Abstract

The acidification response to NH4 Cl loading (0.1 g/kg bw/day) was tested in 16 normal healthy subjects in the basal fasting state on Day 4, the subjects having taken the salt daily for the 3 previous days. The response was measured in terms of blood pH and in urine, creatinine, phosphate, pH, titratable acidity, ammonium, net acidity and creatinine clearance. To minimise inter-subject variation the urine values were adjusted to a standard body surface area of 1.73 m2. A normal range for the blood pH of the mean value +/- 2 SD, encompassed the observed range of values. However, to fit the observed range of acid-base values in urine into the 2 SD range required a logarithmic transformation of the data. Statistical analysis confirmed a significant correlation between blood [H+] net acid secretion, urine titratable acidity and ammonium. Urine net acid secretion was positively correlated with urinary phosphate, titratable acidity and ammonium.

References

Dec 1, 1978·British Journal of Urology·W G RobertsonP B Clark
Jan 1, 1985·American Journal of Nephrology·M L HalperinB J Stinebaugh
Oct 1, 1974·The Journal of Clinical Endocrinology and Metabolism·H J RodriguezE Slatopolsky
Dec 1, 1984·European Journal of Clinical Investigation·M Megevand, H Favre
May 1, 1982·The American Journal of Medicine·D BatlleN A Kurtzman
Nov 1, 1982·The Journal of Urology·J W KonnakK Lau

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Citations

Aug 1, 1993·British Journal of Urology·T M ReynoldsM D Penney
Aug 24, 1999·Annals of Clinical Biochemistry·M D Penney, D A Oleesky

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