The actin cortex at a glance

Journal of Cell Science
Priyamvada Chugh, Ewa Paluch

Abstract

Precisely controlled cell deformations are key to cell migration, division and tissue morphogenesis, and have been implicated in cell differentiation during development, as well as cancer progression. In animal cells, shape changes are primarily driven by the cellular cortex, a thin actomyosin network that lies directly underneath the plasma membrane. Myosin-generated forces create tension in the cortical network, and gradients in tension lead to cellular deformations. Recent studies have provided important insight into the molecular control of cortical tension by progressively unveiling cortex composition and organization. In this Cell Science at a Glance article and the accompanying poster, we review our current understanding of cortex composition and architecture. We then discuss how the microscopic properties of the cortex control cortical tension. While many open questions remain, it is now clear that cortical tension can be modulated through both cortex composition and organization, providing multiple levels of regulation for this key cellular property during cell and tissue morphogenesis.

References

Feb 19, 1988·Science·D Bray, J G White
Nov 1, 1993·The Journal of Cell Biology·D J Fishkind, Y L Wang
Jul 29, 1999·Biophysical Journal·J DaiM A Titus
Dec 28, 1999·Journal of Biomechanics·R M Hochmuth
Aug 3, 2002·Nature Reviews. Molecular Cell Biology·Anthony BretscherRichard G Fehon
Jan 23, 2003·The Journal of Cell Biology·Amy Shaub Maddox, Keith Burridge
Jun 17, 2003·The Journal of Biological Chemistry·Noriko KajiKensaku Mizuno
Jun 29, 2004·Nature Cell Biology·Xiaolong YangTian Xu
Jan 5, 2005·Biochemical and Biophysical Research Communications·Taketsugu FujibuchiKatsumi Kito
Apr 28, 2005·Current Biology : CB·Kausalya Murthy, Patricia Wadsworth
Apr 28, 2005·Current Biology : CB·Minakshi GuhaYu-Li Wang
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sara O DeanJames A Spudich
Nov 8, 2006·The Journal of Cell Biology·Guillaume T CharrasTimothy J Mitchison
Oct 9, 2007·Biophysical Journal·Guillaume T CharrasL Mahadevan
Dec 15, 2007·The Journal of Biological Chemistry·Noriko KajiKensaku Mizuno
Dec 18, 2007·Current Biology : CB·Reza FarhadifarFrank Jülicher
Mar 28, 2008·Nature Cell Biology·M KriegC-P Heisenberg
Mar 29, 2008·Current Biology : CB·Elizabeth M ReichlDouglas N Robinson
May 3, 2008·Nature·Tim LämmermannMichael Sixt
Nov 26, 2008·Nature·Adam C MartinEric F Wieschaus
Feb 19, 2009·Cancer Research·Torsten W RemmerbachJochen Guck
Apr 30, 2009·Annual Review of Biomedical Engineering·Brenton D Hoffman, John C Crocker
Jul 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rajalakshmi NambiarMatthew J Tyska
Oct 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jean-Yves TinevezEwa Paluch
Oct 24, 2009·Nature Reviews. Molecular Cell Biology·Miguel Vicente-ManzanaresAlan Rick Horwitz
Mar 3, 2010·The Journal of Cell Biology·Adam C MartinEric F Wieschaus
Apr 24, 2010·The International Journal of Biochemistry & Cell Biology·Yi-Wen Heng, Cheng-Gee Koh
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·M Lisa ManningEva-Maria Schoetz
Aug 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jan BruguésPierre Sens
Sep 3, 2010·Nature·Clemens CabernardChris Q Doe

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Citations

Jun 19, 2019·Journal of Cell Science·MariaSanta C Mangione, Kathleen L Gould
May 22, 2019·Biomolecules·Joana LeiteAna Xavier Carvalho
Nov 24, 2019·Cytoskeleton·Wonyeong JungTaeyoon Kim
Oct 24, 2019·The Journal of Cell Biology·Tao Jiang, Tony J C Harris
Oct 8, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ricardo H PiresOliver Otto
Oct 13, 2019·The FEBS Journal·Girishkumar Kaitholil Kumaran, Israel Hanukoglu
Mar 19, 2020·Open Biology·Francesca RizzelliMarina Mapelli
Apr 23, 2020·The Journal of Cell Biology·Magdalena MarekSophie G Martin
Jul 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Christian BächerStephan Gekle
Aug 25, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alicia G GubiedaJosana Rodriguez
Jul 11, 2020·Advanced Biosystems·Anna V TaubenbergerJochen Guck
Jul 17, 2020·The Journal of Cell Biology·Yanmei QiShaohua Li
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Lucas Lamparter, Milos Galic
Dec 14, 2018·The Journal of Cell Biology·Aleksandra S ChikinaAntonina Y Alexandrova
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Jing Xie, Nicolas Minc
Jul 6, 2020·Journal of Cell Science·Gloria Mancinelli, Milos Galic
Nov 9, 2019·Soft Matter·Remy KustersCecile Sykes
Jul 31, 2020·Nature·Matthias Rübsam, Carien M Niessen
Jul 17, 2020·The Journal of Cell Biology·Mitsutoshi NakamuraSusan M Parkhurst
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Anna V TaubenbergerHelen K Matthews
Nov 2, 2019·Investigative Ophthalmology & Visual Science·Ying Ying SunKate E Keller
Jul 30, 2020·International Journal of Molecular Sciences·Ignasi CasanellasJosep Samitier
Jun 18, 2020·Cells·Pika Miklavc, Manfred Frick
Sep 16, 2020·International Journal of Molecular Sciences·Jiro Takito, Masanori Nakamura
Oct 22, 2020·Journal of Nanobiotechnology·Ines LüchtefeldMassimo Vassalli
Oct 21, 2020·Nature Materials·Timothée VignaudLaetitia Kurzawa
Nov 12, 2020·Genes·Michaela D Schotanus, Eric Van Otterloo
Nov 26, 2020·International Journal of Molecular Sciences·Kassiani SkouloudakiToby W Hurd
Dec 22, 2020·The Biochemical Journal·Nikita MundharaDulal Panda
Jan 17, 2021·Developmental Cell·Pierre-François LenneVirgile Viasnoff
Nov 26, 2020·Developmental Cell·Valentin GensbittelJacky G Goetz
Jan 29, 2021·ELife·Jaakko I LehtimäkiPekka Lappalainen

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Methods Mentioned

BETA
light microscopy
atomic force microscopy
linear dichroism
super-resolution microscopy
AFM
optical tweezers

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