The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells.

Viruses
Elizabeth Delorme-Axford, Carolyn B Coyne

Abstract

Many diverse viruses target a polarized epithelial monolayer during host invasion. The polarized epithelium is adept at restricting the movement of solutes, ions, macromolecules, and pathogens across the mucosa. This regulation can be attributed to the presence of a junctional complex between adjacent cells and to an intricate network of actin filaments that provides support to the subapical membrane and stabilizes intercellular junctions. It is therefore not surprising that many viruses have evolved highly varied strategies to dissolve or modulate the cortical actin meshwork to promote infection of polarized cells. In this review, we will discuss the cell biological properties of the actin cytoskeleton in polarized epithelial cells and review the known mechanisms utilized by viral pathogens to manipulate this system in order to facilitate their infection.

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Citations

Jul 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yinfeng LiHuajian Gao
May 31, 2013·Journal of Virology·Elizabeth Delorme-AxfordCarolyn B Coyne
Jan 4, 2013·Journal of Virology·Boris LampAndrea Maisner
Nov 16, 2013·PloS One·Roshan PadmashaliStelios T Andreadis
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Apr 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Megan DearnleyLeann Tilley
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Nov 7, 2020·Journal of Cell Science·Yue ZhangYaming Jiu

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Methods Mentioned

BETA
GTPases
IECs
GTPase
fluorescence microscopy

Software Mentioned

CytoD

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