PMID: 6030302Jan 1, 1967

The action of aflatoxin B1 on the rat liver

The Biochemical Journal
J I Clifford, K R Rees


The administration of a single dose of aflatoxin B(1) to the rat (7mg./kg. body wt.) results in the slow development of a periportal necrosis. Hepatic enzymes are released into the serum in the second 24hr. of the poisoning, closely preceding the onset of the necrosis, which is followed by a rise in serum alkaline-phosphatase activity and bilirubin concentration. Aflatoxin B(1) has been detected in the nucleus of the poisoned liver cell and in vitro it has been shown to interact with DNA. The toxin inhibits the production of nuclear RNA, probably by preventing the transcription of DNA by the RNA polymerase. It is proposed that the interaction of the toxin with DNA gives rise to its inhibitory action on mitosis and its necrogenic action.


Dec 17, 2014·Natural Products and Bioprospecting·Can-Bin OuyangMei-Xia Guo
Jan 1, 1994·Research in Veterinary Science·N JindalN K Mahajan
Nov 1, 1990·Journal of Comparative Pathology·G S SinghK K Singh
Oct 1, 1980·Avian Pathology : Journal of the W.V.P.A·W L BrydenA B Lloyd
Mar 1, 1995·British Poultry Science·S K Shukla, S P Pachauri
Apr 1, 1979·Laboratory Animals·O Bassir, T C Alozie
Aug 20, 2014·The American Journal of Tropical Medicine and Hygiene·Nicole J MitchellNii-Ayi Ankrah
May 1, 1970·The Journal of Pathology·M G DeoV Ramalingaswami
Jul 1, 1980·Bulletin of Environmental Contamination and Toxicology·B J McCoy, G C Llewellyn
May 1, 1973·Toxicology and Applied Pharmacology·A W Hayes, C J Hannan
Nov 1, 1968·Archives of Biochemistry and Biophysics·G N Wogan, M A Friedman
May 1, 1972·Toxicology and Applied Pharmacology·H T TungP B Hamilton
Sep 16, 1991·Biochemical and Biophysical Research Communications·J I EwaskiewiczJ J Ch'ih
May 20, 1967·Nature·A J ZuckermanV Petts
Feb 21, 2013·Toxicologic Pathology·Guoqing QianJia-Sheng Wang
Jun 1, 2010·Toxins·Jeanette I Webster Marketon, Esther M Sternberg
Oct 1, 1990·Cell Biology and Toxicology·M N BlaudeM B Roberfroid
Jan 1, 1971·Molecular & General Genetics : MGG·T M Ong
Feb 1, 1973·FEBS Letters·A SarasinN Darracq
Feb 1, 1969·The Journal of Pathology·P A Riley
Jan 1, 1984·Journal of the Science of Food and Agriculture·H T Ostrowski-Meissner
Apr 6, 1968·Nature·Y Moulé, C Frayssinet
Sep 1, 1976·Journal of the American Oil Chemists' Society·P WellsR B Alfin-Slater
Apr 28, 1976·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·H R PrasannaT A Venkitasubramanian
Jun 1, 1975·European Journal of Biochemistry·A Sarasin, Y Moulé
Jan 1, 1970·Journal of Dairy Science·G P LynchL A Moore
Oct 9, 2009·Phytotherapy Research : PTR·Mirian M MendesVeridiana M Rodrigues
May 1, 1975·Bulletin of Environmental Contamination and Toxicology·M R PaiT A Venkitasubramanian
Jun 1, 1970·The Journal of Applied Bacteriology·J M Barnes
Sep 7, 2013·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Tayeb WafaHammami Mohamed
Oct 15, 1979·International Journal of Cancer. Journal International Du Cancer·M H MirmomeniH Emami
Jun 5, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Md Sakib HossenMd Ibrahim Khalil
Jul 15, 1970·International Journal of Cancer. Journal International Du Cancer·C Lafarge, C Frayssinet
Mar 6, 2003·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·M I YousefF D El-Nouty
Jun 1, 1978·Bulletin of Environmental Contamination and Toxicology·G C Llewellyn
Sep 15, 1975·International Journal of Cancer. Journal International Du Cancer·M O ReynierC Frayssinet
Jul 1, 1969·Die Naturwissenschaften·H Bösenberg
Jun 30, 1977·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·F Kiermeier, M Buchner
Oct 30, 1970·Annals of the New York Academy of Sciences·G N Wogan, R S Pong
Jan 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin Klvana, Urban Bren
Jan 1, 1968·Zeitschrift für allgemeine Mikrobiologie·J Reiss

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