PMID: 6030302Jan 1, 1967

The action of aflatoxin B1 on the rat liver

The Biochemical Journal
J I Clifford, K R Rees

Abstract

The administration of a single dose of aflatoxin B(1) to the rat (7mg./kg. body wt.) results in the slow development of a periportal necrosis. Hepatic enzymes are released into the serum in the second 24hr. of the poisoning, closely preceding the onset of the necrosis, which is followed by a rise in serum alkaline-phosphatase activity and bilirubin concentration. Aflatoxin B(1) has been detected in the nucleus of the poisoned liver cell and in vitro it has been shown to interact with DNA. The toxin inhibits the production of nuclear RNA, probably by preventing the transcription of DNA by the RNA polymerase. It is proposed that the interaction of the toxin with DNA gives rise to its inhibitory action on mitosis and its necrogenic action.

Citations

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Related Concepts

Aflatoxins
Carbon Isotopes
DNA, Double-Stranded
Glutamate Dehydrogenase
Isocitrate Dehydrogenase-I
Leucine
Liver
Malate Dehydrogenase
Necrosis
Zinc Orotate

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