PMID: 3761Mar 11, 1976Paper

The action of Ca2+ , Mg2+ and H+ on the contraction threshold of frog skeletal muscle: Evidence for surface charges controlling electro-mechanical coupling

Pflügers Archiv : European journal of physiology
M Dörrscheidt-Käfer

Abstract

The dependence of the threshold potential for contraction of pH and the concentration of Ca2+ and Mg2+ in the bathing solution was measured in frog skeletal muscle. Decreasing the pH from 10.3 to 4.65 resulted in a threshold shift to more positive potentials. Between pH 6.5 and 8.5 the concentration threshold was almost pH -independent. Increasing [Ca2+]o (in the concentration range 0.5-50 mM) shifted the curves relating contraction threshold to pH to less negative potentials and diminished the overall pH-dependence. The contraction threshold exhibited a similar dependence on [Ca2+]o and [Mg2+]o, the two curves running parallel in the concentration range of 5-50 mM, but Mg2+ was only c. 0.6 as effective as Ca2+. To explain these results a surface charge model is proposed which assumes that two acidic groups, sigma1 and sigma2, and one basic group, sigma3, reside at the outer surface of the membrane of the T-system. Alterations in the extracellular medium exert their influence on the electro-mechanical coupling process by changing the surface potential. The groups will be titrated by protons and their charges screened off by the divalent cations. In addition, Ca2+ was supposed to bind with a weak dissociation constant (23 M) to ...Continue Reading

References

Mar 1, 1976·The Journal of General Physiology·D T Campbell, B Hille
Jun 10, 1975·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B HilleB I Shapiro
Jul 1, 1975·The Journal of General Physiology·T Begenisich
May 1, 1973·The Journal of Physiology·A F Dulhunty, P W Gage
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R U Muller, A Finkelstein
Jun 23, 1972·Biochimica Et Biophysica Acta·C M ArmstrongP Horowicz
Jun 1, 1973·The Journal of General Physiology·A M Woodhull
Jan 1, 1974·Pflügers Archiv : European journal of physiology·H Drouin, B Neumcke
Oct 17, 1973·Pflügers Archiv : European journal of physiology·E Stefani, D J Chiarandini
Jan 1, 1973·Pflügers Archiv : European journal of physiology·T Hartz, W Ulbricht
Jan 1, 1974·Pflügers Archiv : European journal of physiology·W Vogel
May 1, 1972·The Journal of Physiology·L E Ford, R J Podolsky
Dec 1, 1971·The Journal of General Physiology·S G McLaughlinG Eisenman
Sep 1, 1969·The Journal of Physiology·R H AdrianA L Hodgkin
Jan 1, 1969·Pflügers Archiv : European journal of physiology·H Drouin, R The
Feb 1, 1968·The Journal of General Physiology·B Hille
Mar 1, 1968·The Journal of General Physiology·M P Blaustein, D E Goldman
Feb 1, 1966·Biochemistry·N E GoodR M Singh
Mar 1, 1967·Acta Physiologica Scandinavica·B Frankenhaeuser, J Lännergren
Apr 1, 1967·The Journal of Physiology·R Elul
Nov 1, 1966·The Journal of General Physiology·B A Curtis
Jul 11, 1957·The Journal of Physiology·B FRANKENHAEUSER, A L HODGKIN
Jul 11, 1957·The Journal of Physiology·B FRANKENHAEUSER
Jul 14, 1958·The Journal of Physiology·B FRANKENHAEUSER, H MEVES
Mar 20, 1959·The Journal of General Physiology·C P BIANCHI, A M SHANES
Oct 1, 1963·The Journal of Physiology·H C LUETTGAU

❮ Previous
Next ❯

Citations

Feb 1, 1987·Pflügers Archiv : European journal of physiology·C Léoty, J Noireaud
Jun 12, 1979·Pflügers Archiv : European journal of physiology·M Dörrscheidt-Käfer
Jun 12, 1979·Pflügers Archiv : European journal of physiology·M Dörrscheidt-Käfer
Jul 19, 1977·Pflügers Archiv : European journal of physiology·M Dörrscheidt-Käfer
Jan 1, 1983·The Journal of Membrane Biology·M Dörrscheidt-Käfer
Jan 1, 1985·Progress in Biophysics and Molecular Biology·J CailléO Rougier
Jan 1, 1992·Progress in Biophysics and Molecular Biology·A F Dulhunty
Feb 1, 1983·The Journal of General Physiology·J A DaniB Hille
Jul 17, 1998·Anesthesiology·M N Gomez
Jul 12, 1979·Nature·W SpieckerH C Lüttgau
Aug 1, 1984·Journal of Muscle Research and Cell Motility·K W Snowdowne, J N Howell
Feb 27, 1998·Journal of Muscle Research and Cell Motility·G S Posterino, G D Lamb
Aug 1, 1989·Archives internationales de physiologie et de biochimie·G Raymond
Sep 1, 1987·The American Journal of Physiology·D J Chiarandini, J Jacoby

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.