The action of dantrolene on transmitter mobilization at the rat neuromuscular junction

European Journal of Pharmacology
N N DurantR L Katz

Abstract

Dantrolene sodium (20 microM) was found to decrease transmitter mobilization and the apparent available store of acetylcholine at frequencies of nerve stimulation of 50 and 100 Hz at the neuromuscular junction of the rat hemidiaphragm preparation treated with 2 microM (+)-tubocurarine. This effect of dantrolene sodium was not as marked at frequencies of nerve stimulation of 25 Hz or less, also no significant effect of the drug was observed on the amplitude of endplate potentials (EPPS) at any frequency of nerve stimulation. No effect of dantrolene sodium (20 microM) on mean miniature EPP amplitude or frequency was observed. It is suggested that the action of dantrolene sodium on mean EPP quantal content may be due to an action on stores of bound calcium within the motor nerve terminal. This effect of the drug is unlikely to be of physiological consequence in vivo, since it was only observed at high frequencies of nerve stimulation and did not cause a significant reduction of EPP amplitude during trains of stimuli.

References

Oct 1, 1977·The Journal of Pharmacy and Pharmacology·W C BowmanA O Savage
Jan 1, 1977·Journal of Neuroscience Research·R J Person
Nov 1, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·R L Volle, D D Branisteanu
Jul 1, 1979·Canadian Journal of Physiology and Pharmacology·D M Quastel
Sep 1, 1976·European Journal of Pharmacology·H E Statham, C J Duncan
Jan 1, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·D D BranisteanuR L Volle
Jun 1, 1975·European Journal of Pharmacology·H E Lowndes
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·K O Ellis, S H Bryant
Aug 2, 1969·Nature·J I HubbardM Miyamoto
Mar 1, 1974·Clinical and Experimental Pharmacology & Physiology·M W Nott, W C Bowman
Feb 1, 1971·Southern Medical Journal·S B ChyatteB A Bergman

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Citations

Sep 1, 1982·Cellular and Molecular Neurobiology·R P Ebstein, J W Daly
Jan 1, 1984·Canadian Anaesthetists' Society Journal·B A Britt
Mar 1, 1984·Canadian Anaesthetists' Society Journal·B A BrittL Endrenyi
Jun 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·I ThomsonC J Kenyon
Sep 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·J M FernandezM Boada

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