PMID: 6258182Dec 1, 1980Paper

The action of leukotriene B4 (LTB4) on the lung

Prostaglandins and Medicine
P SiroisG Girard

Abstract

The actions of leukotriene B4 (LTB4), a member of a newly discovered pathway of metabolism of arachidonic acid, were investigated both on the guinea-pig perfused lung preparation and on the parenchymal strip and compared to histamine and Slow Reacting Substance of Anaphylaxis (SRS-A). LTB was prepared from human polymorphonuclear leukocytes, extracted and purified by chromatography (Silicic acid and HPLC) and its purity was determined by gas chromatography and mass spectrometry. LTB4 is three times more potent than histamine (molar concentration) to contract the parenchymal strips and the contraction to LTB4 as well as to SRS-A lasted longer. The contraction to LTB4 is blocked by indomethacin (20 micrograms/ml), reduced by polyphloretin phosphate (50 micrograms/ml) and unaffected by FPL-55712 (1 micrograms/ml). Following its injection in the pulmonary artery of a perfused lung, LTB4 (1 microgram) induced the release of RCS (Rabbit Aorta Contracting Substance: a mixture of prostaglandins and thromboxanes) which can be abolished by indomethacin (1 microgram/ml). These findings suggest (a) that in the lung, LTB4 is a myotropic agent three times more powerful than histamine (b) that LTB4 stimulated a receptor which is different of ...Continue Reading

References

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Citations

Oct 1, 1986·Agents and Actions·M A Bray
May 1, 1986·Prostaglandins·J E Thorpe, C G Murlas
Dec 1, 1986·Prostaglandins·D W Busija, C W Leffler
Nov 1, 1990·Prostaglandins·A J de Brum-FernandesP Sirois
Jan 1, 1984·Prostaglandins, Leukotrienes, and Medicine·M N Samhoun, P J Piper
Jan 1, 1987·General Pharmacology·E D Högestätt, T K Uski
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A O FelsW A Scott
Oct 1, 1981·The Journal of Experimental Medicine·R A LewisE J Corey
Feb 1, 1982·The Journal of Experimental Medicine·A JörgS J Klebanoff
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Jul 1, 1987·The American Review of Respiratory Disease·J G GarciaA B Malik
May 11, 1991·The American Review of Respiratory Disease·W R Henderson
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Feb 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S A SilbaughW T Jackson
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