PMID: 6162452Jun 15, 1980Paper

The action of Nupercaine on calcium efflux from rat liver mitochondria

The Biochemical Journal
A P Dawson, D V Fulton

Abstract

1. Nupercaine inhibits the Ca2+ efflux from rat liver mitochondria observed in the presence of Ruthenium Red, 50% inhibition being obtained at 80 microM-Nupercaine. 2. Neither the Ruthenium Red-stimulated efflux nor its inhibition by Nupercaine can be directly attributed to effects on mitochondrial stability. 3. Nupercaine perturbs the steady-state external Ca2+ concentration in the absence of Ruthenium Red to an extent that is explicable in terms of the inhibition of Ca2+ efflux. 4. Various factors that are likely to be involved in determining steady-state extra-mitochondrial Ca2+ concentrations are discussed.

Citations

Oct 1, 1985·Cell Calcium·G D SchellenbergP D Swanson
Oct 6, 1999·Biochemical Pharmacology·A FloridiE Arcuri
Oct 1, 1982·European Journal of Biochemistry·F Zoccarato, D Nicholls
Dec 1, 1982·Journal of Bioenergetics and Biomembranes·M S Jurkowitz, G P Brierley
Nov 1, 1982·European Journal of Biochemistry·L M MaglovaY V Evtodienko
Jul 17, 1995·Biochimica Et Biophysica Acta·M Zoratti, I Szabò
Jan 1, 1983·Pharmacology & Therapeutics·W M TaylorF L Bygrave
Jan 1, 1983·General Pharmacology·J Z Byczkowski, C W Porter
Sep 1, 1982·Biochimica Et Biophysica Acta·D Nicholls, K Akerman
Aug 1, 1985·Archives of Biochemistry and Biophysics·G Fiskum, R S Cockrell
Nov 15, 1985·Archives of Biochemistry and Biophysics·R S Cockrell
May 1, 1983·Archives of Biochemistry and Biophysics·M S JurkowitzG P Brierley

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