The action of prostaglandin E2 and F1alpha on myocardial ischaemia-infarction arrhythmias in the dog

C J HarvieM J Walker


Prostaglandin E2 and F1alpha infusions have been tested for their ability to reduce the arrhythmias associated with occlusion of the left descending coronary artery in the anaesthetised dog. At 1 microgram/kg/min both PGs reduced the incidence of premature ventricular contractions occurring during 25-min occlusions, while not reducing the incidence of ventricular fibrillation occurring on occlusion release. When infused for 5-min periods at 1 to 16 microgram/kg/min, neither PGE2 nor PGF1alpha effectively reduced the frequency of ventricular arrhythmias occurring 24 hr after a permanent coronary occlusion.


Jan 1, 1977·Annual Review of Pharmacology and Toxicology·P Hedqvist
May 1, 1978·The American Journal of Digestive Diseases·E Z DajaniR E Bertermann
Nov 1, 1975·The American Journal of Cardiology·P J AxelrodB Lown
Dec 1, 1973·European Journal of Pharmacology·G J Kelliher, T M Glenn
May 1, 1972·European Journal of Pharmacology·W G ZijlstraA J Vergroesen


Mar 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H J Mest, J Rausch
Jul 1, 1980·Medical Hypotheses·J LiebA Nazzaro
Jan 1, 1983·The Journal of Emergency Medicine·W C Lucke, H Thomas
Jan 1, 1996·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E V TibiriçáR S Cordeiro
Nov 1, 1981·Prostaglandins and Medicine·H J Mest, W Förster

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