The action of somatostatin on neurones of the myenteric plexus of the guinea-pig ileum

The Journal of Physiology
Y Katayama, R A North

Abstract

1. Intracellular recordings were made from neurones in ganglia of the myenteric plexus of the guinea-pig ileum. 2. Somatostatin (10-300 nM) was applied to the neurones by adding it to the perfusing solution or by ejecting it (charges up to 500 nC) from an ionophoresis electrode onto the soma membrane. 3. By both methods of application, somatostatin either hyperpolarized or depolarized a proportion of neurones. Depolarizing responses were more often observed with ionophoretic application, and hyperpolarizing responses were more often observed with application by perfusion. Both responses were preserved in solutions containing zero Ca and elevated (6 mM) Mg. Some cells were both hyperpolarized and depolarized, depending on the method of administration. 4. The depolarizing responses to somatostatin were associated with an increase in cell input resistance; they became larger with membrane depolarization and smaller with membrane hyperpolarization, and reversed in polarity at a potential close to the potassium equilibrium potential. The hyperpolarizing responses to somatostatin were accompanied by a fall in cell input resistance.

Citations

Feb 1, 1996·Micron : the International Research and Review Journal for Microscopy·G K Zupanc
Dec 1, 1986·Cellular and Molecular Neurobiology·A L MuellerP A Schwartzkroin
May 1, 1993·Progress in Neurobiology·S Mihara
Oct 14, 2005·Obesity Research·Filippo CremoniniDuane Burton
Sep 29, 1987·Brain Research·A L Willard, R Nishi
Jan 1, 1981·Annals of the New York Academy of Sciences·R J MillerJ Rivier
Nov 13, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Vito Domenico Corleto
Sep 13, 2019·International Journal of Molecular Sciences·Slawomir Gonkowski, Liliana Rytel
Sep 1, 1989·British Journal of Pharmacology·R A North
Mar 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Faiza AbduDavid Grundy
Jan 1, 1988·Life Sciences·J J Galligan, R A North
Jan 1, 1989·Pharmacology & Therapeutics·G S Taylor, R A Bywater

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