The action of substance P on neurons of the myenteric plexus of the guinea-pig small intestine

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
Y KatayamaJ T Williams

Abstract

Extracellular and intracellular recordings were made in vitro from single neurons of the myenteric plexus of the guinea-pig small intestine. Synthetic substance P was applied to the neurons by means of the perfusing solution or by electrophoresis from micropipettes. Extracellular recording showed that substance P (100 pm-30 nm), applied by perfusion, increased the firing rate of myenteric neurons. Intracellular recording indicated that perfusion with substance P caused a dose-dependent membrane depolarization which was unaffected by hexamethonium, hyoscine, naloxone or baclofen. The depolarization was also evoked by electrophoretic application of substance P. It was associated with an increase in membrane resistance, augmented by membrane depolarization and reduced by membrane hyperpolarization. The relation between the substance P reversal potential and the logarithm of the extracellular potassium concentration was linear with a slope of 54 mV/log10[K+], which indicates that substance P inactivates the resting potassium conductance of the myenteric neurons. This effect on ion conductance is the same as that of an unknown substance that mediates slow synaptic excitations with the myenteric plexus.

References

Jul 28, 1977·Nature·J Davies, A Dray
Apr 30, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·R FrancoJ B Furness
Apr 6, 1979·Brain Research·J T Williams, R A North
Feb 1, 1979·Neuropharmacology·N J Dun, A G Karczmar
May 31, 1978·Pflügers Archiv : European journal of physiology·J D Wood, C J Mayer
Jan 1, 1975·Histochemistry·A G Pearse, J M Polak
Jan 1, 1975·Histochemistry·G NilssonF Sundler
Jun 1, 1975·Canadian Journal of Physiology and Pharmacology·J L HenryM E Morris
Oct 24, 1975·Brain Research·K SaitoM Otsuka
May 14, 1976·Brain Research·J Davies, A Dray
Jun 1, 1973·The Journal of Physiology·S Nishi, R A North
Mar 29, 1974·Brain Research·J W Phillis, J J Limacher
Jun 1, 1974·Canadian Journal of Physiology and Pharmacology·K Krnjević, M E Morris
Jan 1, 1974·The Journal of Physiology·G D HirstI Spence
Jun 6, 1931·The Journal of Physiology·U S V Euler, J H Gaddum
Dec 14, 1934·The Journal of Physiology·J H Gaddum, H Schild

Citations

Oct 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·H KilbingerP Holzer
Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·P Holzer
Feb 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·M CostaJ C Bornstein
Apr 1, 1989·Digestive Diseases and Sciences·J ChristensenT M O'Dorisio
Jul 15, 1985·Experientia·M D GershonT Branchek
Dec 1, 1996·Histochemistry and Cell Biology·B R SouthwellJ B Furness
Nov 16, 1979·European Journal of Pharmacology·J T WilliamsR A North
Jul 16, 1982·European Journal of Pharmacology·K TsouE L Way
Jun 16, 1982·European Journal of Pharmacology·J P Huidobro-ToroJ M Musacchio
Oct 14, 1983·European Journal of Pharmacology·H J CheesemanG Henderson
Mar 22, 1988·European Journal of Pharmacology·P R Wade, J D Wood
Jan 28, 1992·European Journal of Pharmacology·M Hanani, J D Wood
Dec 1, 1983·Journal of the Autonomic Nervous System·J P NielG S Taylor
Sep 1, 1988·Journal of the Autonomic Nervous System·B F King, J H Szurszewski
Nov 16, 1982·Neuroscience Letters·A Dray, R D Pinnock
Nov 23, 1987·Neuroscience Letters·J J GalliganR A North
Jan 1, 1980·Neuroscience·J B Furness, M Costa
Jan 1, 1981·Neuroscience·K Morita, R A North
Feb 1, 1982·Neuroscience·R A North
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S Holmgren
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Jun 6, 2000·Trends in Neurosciences·R A North
Jan 1, 1994·Baillière's Clinical Endocrinology and Metabolism·K McConalogue, J B Furness
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y NakajimaK Yamaguchi
Aug 1, 1982·Acta Physiologica Scandinavica·S LeanderR Uddman
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·D BajicY Nakajima
Jan 1, 1988·Life Sciences·J J Galligan, R A North
Jan 1, 1985·Regulatory Peptides. Supplement·D A BrownA Constanti
Dec 1, 2005·The Journal of Peptide Research : Official Journal of the American Peptide Society·E J KimN G Park
Jun 1, 1993·Journal of Neurochemistry·C J MussapE Burcher
Aug 1, 1982·The British Journal of Venereal Diseases·C S EasmonS G Dawson
May 15, 2009·Biological Reviews of the Cambridge Philosophical Society·Clare McW H BenskinIan R Hartley
Aug 14, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M R Matthews, A C Cuello
Sep 29, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Carina Guimarães de Souza MeloDavid R Linden
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J D Wood, A Kirchgessner
Aug 1, 1985·British Journal of Pharmacology·E CherubiniR A North

Related Concepts

Nerve Impulses
Metazoa
Cavia porcellus
Intestines, Small
Resting Potentials
Myenteric Plexus
Neurons
Hypothalamic Substance P

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