PMID: 14403929Mar 1, 1960Paper

The action of sympathetic blocking agents on isolated and innervated atria and vessels

British Journal of Pharmacology and Chemotherapy
S HUKOVIC

Abstract

A preparation is described of isolated rabbit atria with both vagus and sympathetic nerves. The action on it of bretylium and of choline 2,6-xylyl ether bromide (TM10) was studied. A concentration of breylium sufficient to abolish the response to sympathetic stimulation also depressed the response to vagal stimulation. The effect was reversible, though more easily with choline xylyl ether. Both drugs abolished the accelerating action of acetylcholine in the presence of atropine, but they augmented the action of tyramine, and did not reduce that of amphetamine. In the vessels of the perfused rabbit ear they abolished the constrictor effect of nervous stimulation and of acetylcholine, but increased that of tyramine.

References

Dec 1, 1954·British Journal of Pharmacology and Chemotherapy·P HEY, G L WILLEY
Sep 1, 1957·British Journal of Pharmacology and Chemotherapy·K A EXLEY
Jul 11, 1959·Lancet·A L BOURAM L ROSENHEIM
Mar 15, 1948·The Journal of Physiology·R P Stephenson

❮ Previous
Next ❯

Citations

Jun 1, 1971·Comparative and General Pharmacology·B J Gannon
May 1, 1967·European Journal of Pharmacology·M J Rand, J Wilson
Feb 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·R D O'BrienM E Eldefrawi
Oct 1, 1961·British Journal of Pharmacology and Chemotherapy·B G BENFEY, K GREEFF
Oct 1, 1961·British Journal of Pharmacology and Chemotherapy·M D DAY, M J RAND
Apr 1, 1962·British Journal of Pharmacology and Chemotherapy·R J JARRETT
Oct 1, 1967·British Journal of Pharmacology and Chemotherapy·T B Bolton
Aug 1, 1967·British Journal of Pharmacology and Chemotherapy·S D GokhaleV V Kelkar
Jul 1, 1968·British Journal of Pharmacology and Chemotherapy·P C Arya, O D Gulati
May 1, 1967·British Journal of Pharmacology and Chemotherapy·S D GokhaleD I Panchal
Dec 1, 1962·British Journal of Pharmacology and Chemotherapy·P HOLTON, M J RAND
Jan 1, 1962·American Heart Journal·J W ECKSTEIN, F M ABBOUD
Sep 1, 1962·The Journal of Pharmacy and Pharmacology·M D DAY, M J RAND
Mar 1, 1962·Circulation Research·J P GILMORE, J H SIEGEL
Nov 1, 1971·Circulation Research·M N Levy
Oct 21, 2018·British Journal of Pharmacology·Ekaterini Tiligada, Madeleine Ennis
Apr 29, 1998·British Journal of Pharmacology·S LäerJ Neumann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.