Nov 1, 1975

The action of tributyltin on energy coupling in coupling-factor-deficient submitochondrial particles

The Biochemical Journal
A P Dawson, M J Selwyn

Abstract

1. Tributyltin at concentrations of approx. 1nmol/mg of protein induces respiratory control and lessens the protein permeability of coupling-factor-deficient submitochondrial particles. 2. At these concentrations or lower, it increases the P/O ratio of the particles to a small extent and inhibits the adenosine triphosphatase activity without greatly increasing its sensitivity to uncoupling agents. 3. It fails to stimulate ATP-driven reversed electron transport or transhydrogenase, but stimulates the transhydrogenase driven by aerobic succinate oxidation. 4. The results indicate that, unlike oligomycin, tributyltin does not discriminate between damaged and intact ATP-synthesizing complexes. 5. The relationship between the oligomycin- and tributyltin-binding sites is discussed.

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Mentioned in this Paper

Uncoupling Agents
Tributyltin
Complex (molecular entity)
Energy Metabolism
Electron Transport
Succinates
NADH
Oxidation
Succinate
Oligomycins

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