The Action Representation Elicited by Different Types of Drug-Related Cues in Heroin-Abstinent Individuals

Frontiers in Behavioral Neuroscience
Hong ZengHaosheng Ye

Abstract

Drug related cue-induced reactivity plays a significant role in maintaining drug use and relapse in addicted individuals. The activation of Dorsolateral striatum-Sensorimotor system (DLS-SM) has been suggested as an important route through which drug cues may induce automatic drug using behavior. The current study used fMRI to investigate the reactivity of heroin abstinent individuals to different types of cues, to clarify the characteristics of the cues that induce the activation of the sensorimotor area. Forty heroin-dependent abstinent individuals and 29 healthy subjects were recruited to perform the heroin cue-reactivity task during fMRI. The participants' subjective craving and physical signs were evaluated before and after scanning. Whole-brain analysis showed that compared to drug use tool and drug cues, cues related to drug use action were more likely to activate posterior central gyrus, para-hippocampus, supra marginal gyrus, superior parietal lobule (SPL) and inferior parietal lobule (IPL). These areas are involved in motor preparation and output, indicating that the sensorimotor area is also an important neural basis of craving and automatic drug using behavior, and may mediate craving and drug seeking behavior. Our ...Continue Reading

References

Mar 11, 1977·Science·C P O'BrienB Wells
Nov 1, 1971·Psychosomatics·W W Zung
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·S GrantA Margolin
Oct 3, 2002·The American Journal of Psychiatry·Rita Z Goldstein, Nora D Volkow
Dec 10, 2002·Archives of General Psychiatry·Arthur L BrodyMurray E Jarvik
Jun 26, 2004·Annual Review of Neuroscience·Giacomo Rizzolatti, Laila Craighero
Jan 11, 2005·Trends in Cognitive Sciences·Pierre Jacob, Marc Jeannerod
Oct 28, 2005·Nature Neuroscience·Eric J Nestler
Jan 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Antonia F de C Hamilton, Scott T Grafton
May 11, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·James W Lewis
May 30, 2006·Neuron·Nico U F DosenbachSteven E Petersen
Mar 1, 2007·PloS One·Isabella MutschlerTonio Ball
Apr 3, 2007·Trends in Neurosciences·Wolfram Schultz
May 31, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Laurel J BuxbaumH Branch Coslett
Oct 9, 2007·Journal of Cognitive Neuroscience·Jeffrey M Zacks
Mar 22, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Petroc Sumner, Masud Husain
Oct 10, 2008·Nature Reviews. Neuroscience·Parashkev NachevMasud Husain
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yavor YalachkovMarcus J Naumer
Sep 16, 2009·Behavioural Brain Research·Yavor YalachkovMarcus J Naumer
Jan 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bastian StippekohlRudolf Stark
Sep 28, 2010·Experimental Brain Research·Frédéric BoyPetroc Sumner
Oct 12, 2010·NeuroImage·Maartje LuijtenIngmar H A Franken
Jan 21, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dylan D WagnerTodd F Heatherton
Jan 26, 2011·The European Journal of Neuroscience·Simone Kühn, Jürgen Gallinat
Apr 29, 2011·Journal of Neurophysiology·Yavor Yalachkov, Marcus J Naumer
Oct 21, 2011·Nature Reviews. Neuroscience·Rita Z Goldstein, Nora D Volkow
Dec 31, 2011·NeuroImage·Jeffrey M EngelmannPaul M Cinciripini
Jan 24, 2012·Nature Neuroscience·Federica LucantonioGeoffrey Schoenbaum
Mar 24, 2012·Biological Psychiatry·Laura H CorbitPatricia H Janak
Nov 12, 2013·Neuroscience and Biobehavioral Reviews·Agnes J JasinskaYavor Yalachkov
Jan 7, 2014·Progress in Neurobiology·Joana CabralGustavo Deco
Sep 7, 2014·Neuroscience and Biobehavioral Reviews·Jacqueline M Barker, Jane R Taylor
Jun 28, 2015·Neuroscience·L M YagerS M Ferguson
Mar 5, 2016·Frontiers in Psychiatry·Jarid Goodman, Mark G Packard

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