PMID: 6162516Feb 2, 1981Paper

The actions of cholecystokinin and related peptides on pyramidal neurones of the mammalian hippocampus

Brain Research
J Dodd, J S Kelly

Abstract

The presence of cholecystokinin octapeptide (CCK-8) immunoreactivity in the vicinity of the pyramidal neurones of the mammalian hippocampus has allowed us to investigate the central postsynaptic actions of CCK-8 and a number of related peptides, at a site thought to be innervated by a peptidergic pathway. Intracellular records from pyramidal cells of the CA1 region of the hippocampal slice preparation were used to determine changes in excitability and associated changes in membrane potential and resistance evoked by the pressure application of peptides into the cell body layer, from an independently mounted multibarrelled micropipette. The tetra- and octa-peptide C-terminal fragments of cholecystokinin evoked abrupt and rapidly reversible depolarizations which were accompanied by marked increases in excitability and a decrease in membrane input resistance. A comparison was made of the actions of these peptides with those of glutamate, released by iontophoresis from an adjacent barrel of the same multibarrelled pipette. The rate of onset of the cholecystokinin-evoked response was similar to that of the response evoked by glutamate. C-terminal fragments of gastrin (G-13 and G-14) and bombesin were also found to be excitatory to p...Continue Reading

References

Aug 1, 1979·Canadian Journal of Physiology and Pharmacology·J W Phillis, J R Kirkpatrick
Jun 19, 1975·The New England Journal of Medicine·J H Walsh, M I Grossman
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J E MullerR S Yalow
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R B InnisS H Snyder
Apr 1, 1979·Journal of Neurochemistry·J F Rehfeld, N R Goltermann
Nov 8, 1979·Nature·J GibbsS P Maddison
Dec 1, 1979·Physiology & Behavior·D N LorenzG P Smith
Jan 5, 1979·Science·E Straus, R S Yalow
Jun 26, 1975·The New England Journal of Medicine·J H Walsh, M I Grossman
Mar 29, 1974·Brain Research·J W Phillis, J J Limacher
Aug 1, 1980·Journal of Neuroscience Methods·R DingledineJ S Kelly
Jan 24, 1980·Nature·D V Gallacher, O H Petersen
Jul 14, 1980·Brain Research·P R DoddJ Continho-Netto

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Citations

Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Feb 11, 1991·Synapse·S Fitzpatrick-McElligottF Baldino
Oct 1, 1995·Cellular and Molecular Neurobiology·P BodenJ Hughes
Mar 24, 1987·Brain Research·K Gysling, M C Beinfeld
Oct 22, 1985·European Journal of Pharmacology·P R NemethJ D Wood
Jul 26, 1982·Life Sciences·S E Hays, S M Paul
Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·G E HandelmannC J Cummins
Oct 1, 1983·Neuropeptides·M J Sheehan, J de Belleroche
Nov 1, 1988·Brain Research. Developmental Brain Research·D PelapratM Peschanski
Jun 1, 1990·Brain Research. Developmental Brain Research·N W MogensenJ F Rehfeld
Jul 1, 1990·Trends in Pharmacological Sciences·S Ravard, C T Dourish
Jan 1, 1984·Regulatory Peptides·R W Steigerwalt, J A Williams
Jan 1, 1984·Peptides·J F DeFranceR B Chronister
Sep 1, 1987·Peptides·S E Spencer, W T Talman
Sep 1, 1987·Peptides·F Lotstra, J J Vanderhaeghen

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