PMID: 108752Mar 29, 1979

The actions of dopaminergic and noradrenergic antagonists on conditioned avoidance responses in intact and 6-hydroxydopamine-treated rats

Psychopharmacology
M E TaboadaJ M Monti

Abstract

The actions of various doses of haloperidol, pimozide, clozapine, and phenoxybenzamine were assessed on a conditioned-avoidance response (CAR) in control and 6-hydroxydopamine-treated rats, using a pole-climbing device. Haloperidol proved to be the most potent in disrupting the CAR. Pimozide was about 1.6 times less potent, and clozapine and phenoxybenzamine were approximately 52 and 155 times less potent than haloperidol, respectively. Prior treatment with 6-hydroxydopamine slightly enhanced the sensitivity to some of the doses of the DA and NE antagonists. Significantly lower levels of responding, however, were observed only after the highest dose of primozide. Clonidine was not only ineffective in reverting avoidance decrements, but also induced a further decline of the CAR. Apomorphine produced a partial, but significant, reversal of the haloperidol and pimozide-induced depression of conditioned responses. Regarding the clozapine-pretreated animals, a significant antagonism was observed only with the smaller dose of apomorphine. The highest dose induced a further decline of the CAR. The DA agonist was also ineffective in the phenoxybenzamine-injected rats. Amphetamine was effective in antagonizing the avoidance decrements p...Continue Reading

References

Feb 1, 1978·The Journal of Pharmacy and Pharmacology·P M Laduron, J E Leysen
Dec 1, 1971·British Journal of Pharmacology·R B HolmanM Vogt
Jan 1, 1969·Annual Review of Pharmacology·N E AndénJ Häggendal
Sep 1, 1967·The Journal of Pharmacy and Pharmacology·N E AndénT Hökfelt
May 1, 1970·Life Sciences·N E AndénT Svensson
Oct 1, 1972·European Journal of Pharmacology·M Ruiz, J M Monti
Dec 1, 1972·British Journal of Pharmacology·G BartholiniA Pletscher
May 15, 1972·Life Sciences. Pt. 1: Physiology and Pharmacology·J MajZ Kapturkiewicz
Jan 1, 1970·European Journal of Pharmacology·N E AndénU Ungerstedt
Jan 1, 1967·Psychopharmacologia·J M Monti, A J Hance
Jan 1, 1963·Acta Pharmacologica Et Toxicologica·A CARLSSON, M LINDQVIST

Related Concepts

Mydrial
Metazoa
Apokinon
Avoidance Learning
Brain Chemistry
Isoglaucon
Haldol
Hydroxydopamine
Norepinephrine, (+, -)-Isomer
Phenoxybenzamine Hydrochloride

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