PMID: 2360Dec 1, 1975

The actions of flupenthixol upon 5-hydroxytryptamine-induced aggregation and the uptake of 5-hydroxytryptamine and dopamine by human blood platelets

British Journal of Pharmacology
D J BoullinM W Orr

Abstract

The effects of the alpha- and beta-isomers of flupenthixol on 5-hydroxytryptamine (5-HT)-induced platelet aggregation and on 5-HT and dopamine uptake were investigated. Alpha-Flupenthixol was 185 times more potent than the beta-isomer as an inhibitor of platelet aggregation. In contrast both isomers were equipotent as inhibitors of uptake of 5-HT and dopamine. The data suggest that 5-HT-induced aggregation and uptake are separate processes.

References

Feb 1, 1975·British Journal of Clinical Pharmacology·D J BoullinD G Grahame-Smith
May 1, 1975·British Journal of Pharmacology·P H Kelly, R J Miller
Jan 1, 1973·Acta Pharmacologica Et Toxicologica·I M NielsenA V Christensen
Dec 1, 1969·The British Journal of Psychiatry : the Journal of Mental Science·P J Reiter

Citations

Jan 31, 1977·Psychopharmacology·H Y MeltzerV S Fang
Dec 5, 1980·European Journal of Pharmacology·J R Peters, D G Grahame-Smith
May 13, 1986·European Journal of Pharmacology·M VictorzonE Müller-Schweinitzer
Aug 1, 1979·The Journal of Pharmacy and Pharmacology·A Li Wan Po, W J Irwin

Related Concepts

Blood Platelets
Intropin
Fluanxol
Antihistamines, Classical
Platelet Aggregation
Hydroxytryptamine
Molecular Stereochemistry
Thioxanthenes

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