PMID: 3763059Sep 12, 1986Paper

The actions of ivermectin on cultured chick spinal cord neurons

Neuroscience Letters
K MatsumotoH Fukuda

Abstract

The effects of ivermectin (IVM) on cultured chick spinal neurons sensitive to GABA agonists were investigated. IVM caused a change of membrane potential which was associated with an increase in membrane conductance, apparently reversed at about -40 mV and weakened by repetitive application. Furthermore, this agent did not have any effects on either the actions of GABA agonists on neurons or [3H]GABA efflux from those cells. These results suggest that IVM increases membrane conductance through sites which are different from GABA recognition sites.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·L C FritzA Gorio
Mar 1, 1979·Antimicrobial Agents and Chemotherapy·J R EgertonW C Campbell
Jul 1, 1981·Journal of Neurochemistry·R W Olsen
Mar 1, 1984·Journal of Neurochemistry·M Williams, E A Risley
Apr 6, 1984·European Journal of Pharmacology·G Drexler, W Sieghart

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Citations

Dec 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·B Schönrock, J Bormann
Jul 15, 1989·Biochemical Pharmacology·J M Schaeffer, H W Haines
Jan 1, 1988·General Pharmacology·K MatsumotoH Fukuda
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J YamazakiH Fukuda
Apr 20, 2000·European Journal of Pharmacology·H AdelsbergerJ Dudel

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