The actions of prostaglandins I2 and E2 on arrhythmias produced by coronary occlusion in the rat and dog

T L AuM J Walker


Prostaglandins E2 and I2 were compared with known antiarrhythmics for their actions against arrhythmias produced by occlusion of the left anterior descending coronary artery in the anaesthetised rat while PGI2 was also examined in the dog. PGI2 in the dog suppressed early arrhythmias produced during occlusion but did not influence those produced by occlusion-release or those occurring 24 hours after a permanent occlusion; none of the A,B,C or D series prostaglandins tested markedly reduced 24 hour arrhythmias. In the rat PGE2 was antiarrhythmic against early occlusion arrhythmias (30 minutes occlusion) in a dose related manner (infusions of 1-4 microgram/kg/min) whereas PGI2 infusions potentiated the arrhythmogenic effect of occlusion. PGE2 was as effective an antiarrhythmic as 10mg/kg Org. 6001 which was more effective in this test situtation than dl-propranolol. No obvious mechanisms for the actions of PGE2 or PGI2 were apparent although both agents lowered blood pressure and reduced the size of the occluded zone produced by ligation.


Jan 1, 1977·Annual Review of Pharmacology and Toxicology·P Hedqvist
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B B WekslerE A Jaffe
Jun 29, 1978·Nature·S MoncadaJ R Vane


Nov 1, 1983·Basic Research in Cardiology·U N Das
Jul 20, 1983·The American Journal of Cardiology·G J DustingT J Martin
Jun 17, 1983·European Journal of Pharmacology·J L Bergey, M E Beil
Nov 20, 1990·European Journal of Pharmacology·A TosakiM Paubert-Braquet
Feb 25, 1992·European Journal of Pharmacology·M K PugsleyT M Wong
Jan 21, 1992·European Journal of Pharmacology·L N IgwemezieM J Walker
Dec 27, 1995·European Journal of Pharmacology·M K PugsleyM J Walker
Dec 1, 1982·Prostaglandins·R D NolanT J Martin
Oct 1, 1991·Prostaglandins·M Nakamura, Y S Bakhle
Jan 1, 1985·Molecular Aspects of Medicine·J H BottingM J Walker
Mar 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H J Mest, J Rausch
Jan 1, 1981·General Pharmacology·R J Marshall, E Winslow
Jan 1, 1990·Free Radical Biology & Medicine·M BernierDavid J Hearse
Aug 1, 1993·Journal of Pharmacological and Toxicological Methods·P H CheungM J Walker
Sep 5, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·E S HayesMichael J A Walker
Dec 1, 1989·British Journal of Pharmacology·B A MacleodM J Walker
Nov 11, 1999·European Journal of Pharmacology·A CrinitiP P Campa
Nov 1, 1981·Prostaglandins and Medicine·H J Mest, W Förster
Oct 1, 1984·British Journal of Pharmacology·M J CurtisM J Walker
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·H Vapaatalo

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