PMID: 3746676Apr 1, 1986Paper

The actions of some general anaesthetics on the potassium current of the squid giant axon

The Journal of Physiology
D A Haydon, B W Urban

Abstract

A number of small organic molecules with general anaesthetic action have been examined for their effects on the voltage-dependent potassium current of the squid giant axon. They include representatives of the three classes of anaesthetics examined in previous studies on the sodium current (Haydon & Urban, 1983a, b, c), i.e. the non-polar molecules n-pentane, cyclopentane and CCl4, several n-alkanols and the inhalation anaesthetics chloroform, halothane, diethyl ether and methoxyflurane. Potassium currents under voltage clamp were recorded in intact and in intracellularly perfused axons before, during and after exposure to the test substances, and the records were fitted with equations similar to those proposed by Hodgkin & Huxley (1952). Shifts in the curves of the steady-state activation against membrane potential and reductions in the potassium conductance at 60 or 70 mV membrane potential have been tabulated. On the same intact axons, all the anaesthetics with the exception of methoxyflurane reduced potassium currents less than sodium currents by about a factor of two or more. For the n-alkanols, butanol to decanol, the concentrations required to reduce the potassium current at 60 mV membrane potential by 50% were determined...Continue Reading

Citations

Sep 1, 1988·The Journal of Membrane Biology·N RodríguezJ Requena
Jan 1, 1991·Annals of the New York Academy of Sciences·B W UrbanA B Kauff
Jan 1, 1991·Annals of the New York Academy of Sciences·D L Tanelian, M B MacIver
Feb 18, 2006·Pharmacology & Therapeutics·Bernd W UrbanMartin Barann
Aug 1, 1996·British Journal of Pharmacology·M A WhittingtonR D Traub
Sep 1, 1990·British Journal of Pharmacology·J McGivern, C N Scholfield
Jan 29, 2003·Anesthesiology·Allan Gottschalk, Paul Haney
Feb 8, 2018·Frontiers in Physiology·Ryden ArmstrongNaweed Syed
May 18, 2000·Nature Neuroscience·M C Tresch, O Kiehn
Jun 4, 2012·World Journal of Critical Care Medicine·Cheng ZhouXiang-Dong Chen
Jun 6, 2009·European Journal of Anaesthesiology·Andrea Kopp LugliChristoph H Kindler
Jun 22, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B W Urban, D A Haydon
Feb 17, 1994·Nature·N P Franks, W R Lieb
Jun 20, 2003·Journal of Neurophysiology·Alyson J WoodallNaweed I Syed
Oct 19, 2000·Journal of Basic and Clinical Physiology and Pharmacology·M Perouansky, R A Pearce
Sep 1, 2019·Pharmacological Reviews·Nicholas DenommeGeorge A Mashour
Apr 1, 1994·Progress in Neurobiology·J R Elliott, A A Elliott

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