PMID: 1202196Oct 1, 1975Paper

The actions of volatile anaesthetics on synaptic transmission in the dentate gyrus

The Journal of Physiology
C D Richards, A E White

Abstract

1. The action of four volatile anaesthetics on the evoked synaptic potentials of in vitro preparations of the hippocampus were examined. 2. All four anaesthetics (ether, halothane, methoxyflurane and trichloroethylene) depressed the synaptic transmission between the perforant path and the granule cells at concentrations lower than those required to maintain anaesthesia in intact animals. 3. The population excitatory post-synaptic potential (e.p.s.p.) and massed discharge of the cortical cells (population spike) were depressed at concentrations of the anaesthetics lower than those required to depress the compound action potential of the perforant path nerve fibres. None of the anaesthetics studied increased the threshold depolarization required for granule cell discharge. Furthermore, frequency potentiation of the evoked cortical e.p.s.p.s was not impaired by any of the anaesthetics studied. 4. It is concluded that all four anaesthetics depress synaptic transmission in the dentate gyrus either by reducing the amount of transmitter released from each nerve terminal in response to an afferent volley, or by decreasing the sensitivity of the post-synaptic membrane to released transmitted or by both effects together.

Citations

Mar 1, 1992·Electroencephalography and Clinical Neurophysiology·J L StoneP Roccaforte
Jan 1, 1980·Archives of Toxicology·K G HaglidC Briving
Jul 1, 1993·The Journal of Pharmacy and Pharmacology·K KawabataI Yoshiya
May 1, 1992·Acta Anaesthesiologica Scandinavica·J Berg-Johnsen, I A Langmoen
Nov 1, 1992·General Pharmacology·K Krnjević
Jan 1, 1978·General Pharmacology·C D Richards
Aug 28, 1998·British Journal of Pharmacology·A OuanounouH El-Beheiry
Oct 2, 1998·British Journal of Pharmacology·E D KirsonM Perouansky
Mar 27, 2002·The International Journal of Neuroscience·M OhtaT Hosokawa
Jan 1, 1991·Annals of the New York Academy of Sciences·J J KendigS H Roth
Aug 1, 1986·British Journal of Pharmacology·D M Quastel, D A Saint
Sep 1, 1988·British Journal of Pharmacology·G Pocock, C D Richards
Aug 1, 1987·Acta Physiologica Scandinavica·J Berg-Johnsen, I A Langmoen
Dec 1, 1986·Acta Physiologica Scandinavica·J Berg-Johnsen, I A Langmoen
May 1, 1986·Acta Physiologica Scandinavica·J Berg-Johnsen, I A Langmoen
Nov 1, 1986·British Journal of Pharmacology·H Arimura, Y Ikemoto
Jul 2, 2016·Consciousness and Cognition·Oressia Zalucki, Bruno van Swinderen
Oct 1, 2002·Environmental Toxicology and Pharmacology·Lilo AltmannMichael Wilhelm
Jun 11, 2009·British Journal of Anaesthesia·H C Hemmings
Jan 1, 1983·The Journal of International Medical Research·K J Martin
Jun 22, 2016·Clinical EEG and Neuroscience·Martha Itzhel G RamírezDaniel San-Juan
Sep 14, 2017·Anesthesiology·Min-Ching Kuo, L Stan Leung
Oct 1, 1996·Anesthesiology·M B MaclverF A Monroe
Dec 1, 1996·Anesthesiology·M PerouanskyY Yaari
Jan 29, 2003·Anesthesiology·John VotawMark Goodman
Apr 28, 2004·Anesthesiology·Misha PerouanskyRobert A Pearce
Apr 28, 2004·Anesthesiology·Xin-Sheng WuLing-Gang Wu
Nov 24, 1977·Nature·W F WhiteJ T Cummins
Jul 31, 1980·Nature·M F JohnstonF Ramón

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.