PMID: 9450507Feb 5, 1998Paper

The activation of cannabinoid receptors in striatonigral GABAergic neurons inhibited GABA uptake

Life Sciences
J. RomeroJ.J. Fernández-Ruiz

Abstract

Cannabinoid receptors (CNRs) in basal ganglia are located on striatal efferent neurons which are gamma-aminobutiric acid (GABA)-containing neurons. Recently, we have demonstrated that CN-induced motor inhibition is reversed by GABA-B, but not GABA-A, receptor antagonists, presumably indicating that the activation of CNRs in striatal outflow nuclei, mainly in the substantia nigra, should be followed by an increase of GABA concentrations into the synaptic cleft of GABA-B receptor synapses. The present study was designed to examine whether this was originated by increasing GABA synthesis and/or release or by decreasing GABA uptake. We analyzed: (i) GABA synthesis, by measuring the activity of glutamic acid decarboxylase (GAD) and GABA contents in brain regions that contain striatonigral GABAergic neurons, after in vivo administration of CNs and/or the CNR antagonist SR141716; (ii) [3H]GABA release in vitro in the presence or the absence of a synthetic CN agonist, HU-210, by using perifusion of small fragments of substantia nigra; and (iii) [3H]GABA uptake in vitro in the presence or the absence of WIN-55,212-2, by using synaptosomes obtained from either globus pallidus or substantia nigra. Results were as follows. Delta9-tetrahydr...Continue Reading

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Citations

Jan 5, 2002·European Journal of Pharmacology·Malcolm BeggMike Parsons
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·P J MclaughlinJ Brener
Aug 17, 2002·Pharmacology & Therapeutics·Julián RomeroJavier Fernández-Ruiz
Jun 28, 2003·Brain Research. Molecular Brain Research·José Martínez-OrgadoM Paz Viveros
Jun 15, 1999·Progress in Neurobiology·A Ameri
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Camila ScorticatiValeria Rettori
Oct 5, 2001·Alcoholism, Clinical and Experimental Research·F LallemandP H De Witte
Jul 20, 2002·Neuropharmacology·S N DaviesG Riedel
Jan 26, 2007·Journal of Neurochemistry·David A PriceAndrea Giuffrida
Oct 20, 2007·Journal of Neurochemistry·K Yaragudri VinodBasalingappa L Hungund
May 29, 2007·Behavioural Brain Research·T Lorivel, P Hilber
May 26, 2004·Pharmacology, Biochemistry, and Behavior·S M RawlsMartin W Adler
Feb 10, 2010·Journal of Psychopharmacology·Leyre UrigüenJorge Manzanares
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May 1, 2021·Frontiers in Cellular Neuroscience·Renae M RyanAnnalisa Scimemi
Jul 13, 2004·Revue neurologique·P DerkinderenJ-A Girault

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