The activation of microRNA-520h-associated TGF-β1/c-Myb/Smad7 axis promotes epithelial ovarian cancer progression

Cell Death & Disease
Jing ZhangYi Lin

Abstract

Among the gynaecological cancers, epithelial ovarian cancer (EOC) has the highest lethality because of the high incidence of tumour progression and metastasis. Exploration of the detailed mechanisms underlying EOC metastasis and the identification of crucial targets is important to better estimate the prognosis and improve the treatment of this disease. The present study aimed to identify the role of miR-520h in the prognosis of patients with EOC, and the mechanisms of its involvement in EOC progression. We showed that miR-520h was upregulated in 116 patients with EOC, especially in those with advanced-stage disease, and high miR-520h expression predicted poor outcome. Furthermore, ectopic expression of miR-520h enhanced EOC cell proliferation, migration and invasion, and induced epithelial-mesenchymal transition in vitro and in vivo. miR-520h promoted EOC progression by downregulating Smad7, and subsequently activating the TGF-β signalling pathway. Most importantly, TGF-β1 stimulation increased miR-520h expression in EOC cells by upregulating its transcription factor c-Myb. In conclusion, we described the role of the TGF-β1/c-Myb/miR-520h/Smad7 axis in EOC metastasis, and highlighted the possible use of miR-520h as a prognosti...Continue Reading

References

Jun 1, 2002·Science·Liliana Attisano, Jeffrey L Wrana
Aug 27, 2005·Oncogene·Jiri Zavadil, Erwin P Böttinger
Jan 20, 2007·Science·Michelangelo CordenonsiStefano Piccolo
Jul 30, 2008·Cell·Joan Massagué
Feb 26, 2009·Cell·Andrea Ventura, Tyler Jacks
Oct 18, 2011·Cell·Scott Valastyan, Robert A Weinberg
May 1, 2012·Cell·Margaret S Ebert, Phillip A Sharp
Apr 17, 2014·Cancer Cell·Weiying ZhouShizhen Emily Wang
Apr 29, 2014·Lancet·Gordon C JaysonJonathan A Ledermann
Sep 25, 2014·Science Signaling·David M Gonzalez, Damian Medici
Jul 17, 2015·JAMA Oncology·UNKNOWN Global Burden of Disease Cancer CollaborationMohsen Naghavi
Oct 24, 2015·Nature Reviews. Cancer·David D BowtellFrances R Balkwill
May 2, 2016·Cancer Letters·Zhongyue LuoShengtao Zhou
Jul 2, 2016·Cell·M Angela NietoJean Paul Thiery
Oct 9, 2016·Molecular Diagnosis & Therapy·Priya Samuel, David Raul Francisco Carter
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

Jul 10, 2019·Current Drug Targets·Seyed Mostafa ParizadehAmir Avan
Apr 25, 2020·Expert Review of Anticancer Therapy·Huilin Zhang, Bingjian Lu
Aug 2, 2020·American Journal of Reproductive Immunology : AJRI·Shuo ChangJing Yang
Oct 1, 2020·International Journal of Molecular Sciences·Vu Hong Loan NguyenChun Peng
Jul 29, 2019·Apoptosis : an International Journal on Programmed Cell Death·Wei WangTingguo Zhang
Oct 22, 2020·Critical Reviews in Biochemistry and Molecular Biology·Charlotte de Ceuninck van CapellePeter Ten Dijke
Dec 17, 2021·Frontiers in Cell and Developmental Biology·Shuang YuanLihua Wang

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Methods Mentioned

BETA
xenograft
xenografts
transfection
dissecting
ELISA
PCR
immunoprecipitation
ChIP
electrophoresis
enzyme-linked immunosorbent assay

Software Mentioned

PuTmiR
JASPAR
TargetScan
SPSS
PROMO

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