The activation of the atypical PKC zeta in light-induced retinal degeneration and its involvement in L-DNase II control

Journal of Cellular and Molecular Medicine
Imène JaadaneAlicia Torriglia

Abstract

Light-induced retinal degeneration is characterized by photoreceptor cell death. Many studies showed that photoreceptor demise is caspase-independent. In our laboratory we showed that leucocyte elastase inhibitor/LEI-derived DNase II (LEI/L-DNase II), a caspase-independent apoptotic pathway, is responsible for photoreceptor death. In this work, we investigated the activation of a pro-survival kinase, the protein kinase C (PKC) zeta. We show that light exposure induced PKC zeta activation. PKC zeta interacts with LEI/L-DNase II and controls its DNase activity by impairing its nuclear translocation. These results highlight the role of PKC zeta in retinal physiology and show that this kinase can control caspase-independent pathways.

References

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Citations

Apr 12, 2015·Free Radical Biology & Medicine·Imene JaadaneAlicia Torriglia
Jul 17, 2016·Seminars in Cell & Developmental Biology·Alicia TorrigliaImene Jaadane
Jul 1, 2017·Journal of Cellular and Molecular Medicine·Imene JaadaneAlicia Torriglia
Dec 8, 2015·Current Opinion in Neurology·Alicia TorrigliaCecile Lebon
Mar 20, 2020·Physiological Reviews·Sonja KleinlogelTobias Moser
May 14, 2021·Molecular and Cellular Biochemistry·Meenakshi MauryaTara Sankar Roy

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Methods Mentioned

BETA
nuclear translocation
Co-Immunoprecipitation
fluorescence microscopy
Protein Assay
transfection
pull-down
Pull down
co-immunoprecipitations

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