The activation potential of MOF is constrained for dosage compensation

Molecular Cell
Matthias PrestelPeter B Becker

Abstract

The H4K16 acetyltransferase MOF plays a crucial role in dosage compensation in Drosophila but has additional, global functions. We compared the molecular context and effect of MOF in male and female flies, combining chromosome-wide mapping and transcriptome studies with analyses of defined reporter loci in transgenic flies. MOF distributes dynamically between two complexes, the dosage compensation complex and a complex containing MBD-R2, a global facilitator of transcription. These different targeting principles define the distribution of MOF between the X chromosome and autosomes and at transcription units with 5' or 3' enrichment. The male X chromosome differs from all other chromosomes in that H4K16 acetylation levels do not correlate with transcription output. The reconstitution of this phenomenon at a model locus revealed that the activation potential of MOF is constrained in male cells in the context of the DCC to arrive at the 2-fold activation of transcription characteristic of dosage compensation.

References

Oct 6, 2005·Genes & Development·Tobias StraubPeter B Becker
Oct 6, 2005·Genes & Development·Fumika N HamadaMitzi I Kuroda
Nov 16, 2005·Annual Review of Genetics·John C LucchesiBarbara Panning
Nov 22, 2005·Trends in Biochemical Sciences·Mariann Bienz
Feb 14, 2006·Science·Michael Shogren-KnaakCraig L Peterson
Mar 21, 2006·Genes & Development·Gregor D GilfillanPeter B Becker
Apr 15, 2006·PLoS Biology·Nicolas NègreGiacomo Cavalli
Oct 13, 2006·Development·Hirofumi FuruhashiSusumu Hirose
Dec 19, 2006·Nature Reviews. Genetics·Tobias Straub, Peter B Becker
May 31, 2007·Nature Genetics·Venkateswara R ChintapalliJulian A T Dow
Nov 13, 2007·Nature Genetics·Ginger W MuseKaren Adelman
Jul 26, 2008·Journal of Molecular Biology·Philip J J RobinsonDaniela Rhodes
Apr 14, 2009·Development·Marnie E Gelbart, Mitzi I Kuroda
Aug 4, 2009·Nature Structural & Molecular Biology·Marnie E GelbartMitzi I Kuroda

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Citations

Apr 21, 2011·Chromosoma·Per Stenberg, Jan Larsson
Dec 6, 2011·Nature Structural & Molecular Biology·Eda YildirimJeannie T Lee
Jul 19, 2012·Briefings in Functional Genomics·Imre M Boros
May 10, 2011·Nucleic Acids Research·Anna-Mia JohanssonJan Larsson
Sep 2, 2010·Genome Biology·Matthias PrestelPeter B Becker
Mar 23, 2011·PLoS Genetics·Catherine RegnardPeter B Becker
Jun 23, 2012·PLoS Genetics·Kin Chung LamAsifa Akhtar
Aug 12, 2014·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Marcela M L Soruco, Erica Larschan
May 18, 2011·The Journal of Cell Biology·Anne E WhiteRobert J Duronio
Jan 20, 2016·International Journal of Molecular Sciences·Jiaming SuJingji Jin
Jan 13, 2015·Molecular Cell·Christian FellerPeter B Becker
Aug 27, 2011·Journal of Genetics and Genomics = Yi Chuan Xue Bao·James BirchlerAbhijit Sanyal
Feb 15, 2011·Current Opinion in Genetics & Development·Tobias Straub, Peter B Becker
Apr 17, 2016·Current Opinion in Cell Biology·Christopher Ptak, Richard W Wozniak
Jan 11, 2014·Biochimica Et Biophysica Acta·Jessica Chery, Erica Larschan
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lin SunJames A Birchler
Dec 17, 2014·PLoS Genetics·Margarida L A FigueiredoJan Larsson
Aug 5, 2016·Genes, Brain, and Behavior·T GuptaS J Certel
Nov 21, 2018·Life Science Alliance·Alessandro ScacchettiPeter B Becker
Dec 13, 2018·Nucleic Acids Research·Christian AlbigPeter B Becker
Jun 24, 2017·Epigenetics & Chromatin·Gautier RichardGaël Le Trionnaire
Dec 16, 2017·G3 : Genes - Genomes - Genetics·Hangnoh LeeTeresa M Przytycka
May 17, 2017·PloS One·Sarah SchunterPeter B Becker
Jul 10, 2019·EMBO Reports·Khairunnadiya PrayitnoPeter B Becker
Aug 4, 2010·Molecular and Cellular Biology·Ditte Skovaa AndersenNicolas Tapon
Aug 25, 2021·Doklady. Biochemistry and Biophysics·V A BaboshaO G Maksimenko

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