The active and passive ciliary motion in the embryo node: a computational fluid dynamics model.

Journal of Biomechanics
Duanduan ChenYiannis Ventikos

Abstract

The breaking of left-right symmetry in the mammalian embryo is believed to occur in a transient embryonic structure, the node, when cilia create a leftward flow of liquid. The two-cilia hypothesis proposes that the node contains two kinds of primary cilia: motile cilia that rotate autonomously to generate the leftward fluid flow and passive cilia that act as mechano-sensors, responding to flow. While studies support this hypothesis, the mechanism by which the sensory cilia respond to the fluid flow is still unclear. In this paper, we present a computational model of two cilia, one active and one passive. By employing computational fluid dynamics, deformable mesh computational techniques and fluid-structure interaction analysis, and solving the three-dimensional unsteady transport equations, we study the flow pattern produced by the movement of the active cilium and the response of the passive cilium to this flow. Our results reveal that clockwise rotation of the active cilium can generate a counter-clockwise elliptical rotation and overall lateral displacement for its neighboring passive one, of measurable magnitude and consistent pattern. This supports the plausibility of the two-cilia hypothesis and helps quantify the motion ...Continue Reading

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Citations

May 18, 2013·Bulletin of Mathematical Biology·Mark S Thompson
Dec 4, 2010·Medical Engineering & Physics·Duanduan ChenYiannis Ventikos
Jan 25, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael LavagninoKeri Gardner
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May 10, 2015·Journal of Theoretical Biology·Hanifeh KhayyeriDamien Lacroix
Mar 13, 2012·Biophysical Journal·Marek NebylaIgor Schreiber
Apr 15, 2014·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Duanduan ChenYiannis Ventikos
Jan 26, 2018·Journal of Cardiovascular Development and Disease·José A BeloJosé M Inácio
Jun 24, 2020·Seminars in Cell & Developmental Biology·Rosie B Little, Dominic P Norris

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