The activity of an anti-allergic compound, proxicromil, on models of immunity and inflammation

Agents and Actions
R W KeoghT S Orr

Abstract

A tricyclic chromone, proxicromil (sodium 6,7,8,9-tetrahydro-5-hydroxy-4-oxo-10-propyl-naphtho (2,3-b) pyran-2-carboxylate), has been tested for activity against certain immunological and inflammatory reactions. When given parenterally it suppressed the development of delayed hypersensitivity reactions in sensitized mice and guinea-pigs but did not affect the rejection of skin allografts in mice. The compound had no activity against certain in vitro correlates of delayed hypersensitivity reactions (lymphocyte transformation and lymphokine activity), but did have an inhibitory effect on lymphokine (MIF) productions at 10(-4) M but not at 10(-5) M. Proxicromil was also found to be active in non-immunologically mediated models of inflammation and in models having an immunological component which are known to be sensitive to non-steroidal anti-inflammatory drugs (adjuvant arthritis, reversed passive Arthus reaction). The activity of this compound was enhanced when administered in arachis oil when compared to its activity in saline. Proxicromil has not direct activity on the development of immune responsiveness but appear to suppress the expression of delayed hypersensitivity and immune complex mediated hypersensitivity reactions by...Continue Reading

References

Oct 1, 1977·Agents and Actions·J AugsteinP Sheard
Feb 1, 1976·Agents and Actions·S C Meacock, E A Kitchen
Jul 1, 1972·The Journal of Pharmacy and Pharmacology·M Di RosaL Parente
Jan 1, 1980·Clinical Allergy·N C ThomsonJ W Kerr
Apr 1, 1960·Transplantation Bulletin·D W BAILEY, B USAMA
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS
Aug 1, 1963·British Journal of Pharmacology and Chemotherapy·B B NEWBOULD

Citations

Nov 1, 1985·The Journal of Pharmacy and Pharmacology·A BlackhamF A Woods
Nov 1, 1986·Biological Reviews of the Cambridge Philosophical Society·C A Finn
Dec 18, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Chi Chiu WangKwok Pui Fung

Related Concepts

Proxicromil sodium
Metazoa
Anti-Inflammatory Agents
Antibody Formation
Arthritis, Experimental
Arthus Reaction
Chromones
Contact Hypersensitivity
Graft Rejection
Cavia porcellus

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here