The activity of antioxidant enzymes in blood platelets in different types of renal replacement therapy: a cross-sectional study

International Urology and Nephrology
Joanna StepniewskaKazimierz Ciechanowski

Abstract

The changes in redox status characterise physiological platelet activation. Increased oxidative stress in chronic kidney disease (CKD) associated with uremic toxicity and procedures of renal replacement therapy leads to the impairment of antioxidant properties of platelets. It may contribute to thrombosis and cardiovascular complications increasing morbidity and mortality among the CKD patients. The object of the research was to assess the influence of conservative treatment, peritoneal dialysis and haemodialysis on platelet prooxidative-antioxidative balance. The examined group consisted of 122 patients: 37 on regular haemodialysis (HD), 23 on peritoneal dialysis (PD) and 62 on conservative treatment with CKD stages 3-5 (CKD3-5). The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione transpherase (GST) in platelets were obtained using kinetic methods. The spectrophotometric method established the concentrations of reduced glutathione (GSH). SOD activity in PD differs significantly from CKD3-5 (4.96 vs 1.66; p < 0.0001). CAT activity assessed in PD and CKD3-5 was significantly different from HD (0.82 and 0.8 vs 0.52 before and 0.35 after HD, respectively). GST activity reached th...Continue Reading

References

Jan 1, 1984·Methods in Enzymology·H Aebi
Jan 1, 1981·Methods in Enzymology·A Wendel
Jan 1, 1996·Free Radical Biology & Medicine·I Ceballos-PicotB Descamps-Latscha
Nov 14, 1997·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S BiasioliD Giavarina
Oct 30, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·V SchettlerG A Müller
Dec 21, 2000·International Journal of Cardiology·N R PandeyM K Misra
Oct 30, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J Galle
Oct 30, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A KlemmG Stein
Jul 10, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cevahir ErdoğanSelda Bekpinar
Aug 16, 2002·Platelets·B WachowiczAndrzej Buczyński
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Wolfgang H CerwinkaD Neil Granger
Nov 8, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Patricia CluttonJane E Freedman
Sep 18, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Florian KrötzUlrich Pohl
Mar 7, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Danuta ZwołińskaKrystyna Szprynger
Jun 15, 2007·Free Radical Biology & Medicine·Karen Y StokesD Neil Granger
Nov 29, 2007·Platelets·John C SillZvonimir S Katusic
Jan 5, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jane E Freedman
Sep 17, 2008·Clinical Nephrology·R NisselU Querfeld
Jul 5, 2011·Redox Report : Communications in Free Radical Research·Joanna RybkaJózef Kędziora
Aug 26, 2011·Experimental Gerontology·Rocío GuevaraPilar Roca
Sep 24, 2013·Oxidative Medicine and Cellular Longevity·Chih-Chien SungChia-Chao Wu
Feb 1, 2014·Blood Purification·Joanna StępniewskaKazimierz Ciechanowski
Jul 5, 2015·Redox Biology·Jana ViskupicovaIzabela Sadowska-Bartosz

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Citations

Jul 10, 2019·Journal of Cardiovascular Pharmacology and Therapeutics·Eduardo FuentesAndres Trostchansky
May 12, 2018·Oxidative Medicine and Cellular Longevity·Vassilios LiakopoulosPeter R Mertens
May 3, 2019·Seminars in Dialysis·Stefanos RoumeliotisVassilios Liakopoulos
Sep 13, 2020·BMC Nephrology·Elżbieta Cecerska-HeryćBarbara Dołęgowska
Feb 7, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christoffer Juul-NielsenAlexandra Scholze

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