Abstract
Trypanosomiasis belongs to the neglected tropical diseases. Although standard therapies are available, the safety and efficacy of current synthetic drugs are limited due to the development of drug resistance and adverse side effects. Artemisia annua and artemisinin are not only active against Plasmodia, but also other protozoa. Therefore, we reviewed the literature on species of the genus Artemisia and their phytochemicals regarding their activity against trypanosomes. A PubMed search for "Artemisia/Artemisinin and Trypanosoma" has been conducted for literature until December 2017. Interestingly, not only A. annua L. and its active principle, artemisinin revealed inhibitory activity towards trypanosomes. Other Artemisia species (A. absinthium, A. abyssinica, A. afra, A. douglasia, A. elegantissima, A. maciverae, A. mexicana, and A. roxburghiana) also inhibited T. brucei, T. cruzi, or T. congolense. The plants contained numerous chemical constituents including 3',4'-dihydroxybonanzin, apigenin, betulinic acid, bonanzin, dehydroleucodine, dihydroluteolin, dracunculin and bis-dracunculin, helenalin, nepetin, scoparol, scopoletin, stigmasterol, (Z)-p‑hydroxy cinnamic acid, β-sitosterol and others. In addition to artemisinin from A....Continue Reading
Citations
May 7, 2019·International Journal of Environmental Research and Public Health·Amira B MokhtarPanagiotis Karanis
Dec 31, 2019·Journal of Food and Drug Analysis·Ching-Ping TsengPei-Wen Hsieh
Jan 25, 2020·Dose-response : a Publication of International Hormesis Society·Chuanrui ZhengThomas Efferth
Jun 4, 2019·Frontiers in Pharmacology·Roberval Nascimento Moraes NetoAmanda Silva Dos Santos Aliança
Dec 4, 2019·International Journal of Oncology·Mohamed E M SaeedThomas Efferth
Apr 15, 2020·Cancers·Bhavishya SarmaRoland Houben
Feb 3, 2019·Medicines·Sodik NumonovHaji Akber Aisa
Jul 4, 2020·Signal Transduction and Targeted Therapy·Zhe ZhangCanhua Huang
Dec 22, 2020·Frontiers in Pharmacology·María José Larrazábal-FuentesJavier Echeverría
Jul 16, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yulin WangThomas Efferth
Jun 3, 2020·Seminars in Cancer Biology·Xiaohua Lu, Thomas Efferth
Aug 4, 2019·Journal of Ethnopharmacology·Anneke du Toit, Frank van der Kooy
Jan 6, 2021·Foods·Antoaneta TrendafilovaAna M L Seca
Feb 4, 2021·Plant Biology·L NomaniT Aftab
Apr 13, 2021·Computers in Biology and Medicine·Onat KadiogluThomas Efferth
Dec 1, 2019·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·B M GruessnerP J Weathers
Jun 21, 2021·Medicinal Research Reviews·Yuqing MengJigang Wang
Jul 22, 2021·Medicinal Research Reviews·Thomas Efferth, Franz Oesch
Jul 16, 2021·Planta·Kaiser Iqbal WaniTariq Aftab
Aug 3, 2021·Journal of Cellular and Molecular Medicine·Xian-Ying LeiLi Wang
Sep 4, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Kelvin Olutimilehin JolayemiOchuko Orakpoghenor