The activity of Artemisia spp. and their constituents against Trypanosomiasis.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Janine Naß, Thomas Efferth

Abstract

Trypanosomiasis belongs to the neglected tropical diseases. Although standard therapies are available, the safety and efficacy of current synthetic drugs are limited due to the development of drug resistance and adverse side effects. Artemisia annua and artemisinin are not only active against Plasmodia, but also other protozoa. Therefore, we reviewed the literature on species of the genus Artemisia and their phytochemicals regarding their activity against trypanosomes. A PubMed search for "Artemisia/Artemisinin and Trypanosoma" has been conducted for literature until December 2017. Interestingly, not only A. annua L. and its active principle, artemisinin revealed inhibitory activity towards trypanosomes. Other Artemisia species (A. absinthium, A. abyssinica, A. afra, A. douglasia, A. elegantissima, A. maciverae, A. mexicana, and A. roxburghiana) also inhibited T. brucei, T. cruzi, or T. congolense. The plants contained numerous chemical constituents including 3',4'-dihydroxybonanzin, apigenin, betulinic acid, bonanzin, dehydroleucodine, dihydroluteolin, dracunculin and bis-dracunculin, helenalin, nepetin, scoparol, scopoletin, stigmasterol, (Z)-p‑hydroxy cinnamic acid, β-sitosterol and others. In addition to artemisinin from A....Continue Reading

Citations

May 7, 2019·International Journal of Environmental Research and Public Health·Amira B MokhtarPanagiotis Karanis
Jan 25, 2020·Dose-response : a Publication of International Hormesis Society·Chuanrui ZhengThomas Efferth
Jun 4, 2019·Frontiers in Pharmacology·Roberval Nascimento Moraes NetoAmanda Silva Dos Santos Aliança
Dec 4, 2019·International Journal of Oncology·Mohamed E M SaeedThomas Efferth
Jul 4, 2020·Signal Transduction and Targeted Therapy·Zhe ZhangCanhua Huang
Dec 22, 2020·Frontiers in Pharmacology·María José Larrazábal-FuentesJavier Echeverría
Jul 16, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yulin WangThomas Efferth
Jun 3, 2020·Seminars in Cancer Biology·Xiaohua Lu, Thomas Efferth
Aug 4, 2019·Journal of Ethnopharmacology·Anneke du Toit, Frank van der Kooy
Dec 1, 2019·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·B M GruessnerP J Weathers
Jun 21, 2021·Medicinal Research Reviews·Yuqing MengJigang Wang
Jul 22, 2021·Medicinal Research Reviews·Thomas Efferth, Franz Oesch
Sep 4, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Kelvin Olutimilehin JolayemiOchuko Orakpoghenor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Related Papers

Revue d'élevage et de médecine vétérinaire des pays tropicaux
R A Joshua
Enfermedades infecciosas y microbiología clínica
Mariolga Berrizbeitia de MorgadoPierre Lutgen
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Endalkachew Nibret, Michael Wink
Transactions of the Royal Society of Tropical Medicine and Hygiene
L Heide
© 2022 Meta ULC. All rights reserved