PMID: 18200413Jan 18, 2008Paper

The activity of azithromycin against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis in the golden hamster model

Revista Da Sociedade Brasileira De Medicina Tropical
Angel SinagraAlejandro J Krolewiecki

Abstract

New therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania (Leishmania) major has been previously demonstrated. Different responses among species of Leishmania make species-specific drug screening necessary. The activity of azithromycin against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis was evaluated in golden hamsters infected through footpad injections of metacyclic promastigotes, and compared with untreated controls and animals treated with meglumine antimoniate. Footpad thickness, lesion cultures and dissemination sites were analyzed. Treatment of golden hamsters with oral azithromycin at 450mg/kg had no activity against infections with Leishmania (Leishmania) amazonensis. For infections due to Leishmania (Viannia) braziliensis, azithromycin demonstrated significant activity relative to untreated controls, but inferior to meglumine antimoniate, for controlling lesion size. Neither drug was able to totally eliminate parasites from the lesions. It was concluded that azithromycin has activity against Leishmania (Viannia) braziliensis but not against Leishmania (Leishmania) amazonensis in this model.

References

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Nov 1, 2002·The American Journal of Tropical Medicine and Hygiene·Alejandro KrolewieckiDavid Abraham
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Citations

Jul 15, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Eglal I AmerShereen F Mossallam
Apr 14, 2016·Dermatologic Therapy·Omid RajabiMohsen Khoddami
Oct 27, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Edgar H Lizarazo-JaimesCynthia Demicheli

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