The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani

Bioorganic & Medicinal Chemistry Letters
Chad E StephensDavid W Boykin

Abstract

The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC(50) values of less than 1 micro mol versus T. cruzi and five gave similar values versus L. donovani.

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Citations

Sep 10, 2011·Parasitology·Cristiane França DA SilvaMaria D E Nazaré Correia Soeiro
Jun 26, 2013·Journal of Medicinal Chemistry·Donald A PatrickRichard R Tidwell
Aug 19, 2007·Antimicrobial Agents and Chemotherapy·C F SilvaM N C Soeiro
Apr 7, 2010·Antimicrobial Agents and Chemotherapy·Michael Zhuo WangKarl A Werbovetz
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Andrea L CrowellW Evan Secor
Jun 24, 2014·European Journal of Medicinal Chemistry·Zong-ying LiuDavid W Boykin
Nov 23, 2013·Expert Opinion on Drug Discovery·Muhammad Khawar RaufAmin Badshah
Feb 20, 2016·Journal of Computer-aided Molecular Design·Lucas N AlbercaAlan Talevi
Feb 15, 2007·Veterinary Parasitology·Alexa C RosypalRichard R Tidwell
Jan 15, 2010·Journal of Cellular and Molecular Medicine·Silvia Beatriz BoscardinAriel Mariano Silber
Dec 10, 2008·Expert Opinion on Therapeutic Targets·Maria Nazaré C Soeiro, Solange L de Castro
Jul 30, 2005·Expert Opinion on Investigational Drugs·M N C SoeiroD W Boykin
Apr 28, 2007·Biochemical Pharmacology·C F SilvaMaria de Nazaré C Soeiro
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Maria de Nazaré C SoeiroSolange Lisboa de Castro
Apr 7, 2016·Bioorganic & Medicinal Chemistry Letters·Xiaohua ZhuKarl A Werbovetz
Oct 27, 2004·European Journal of Medicinal Chemistry·Márcia Narcizo BorgesJosé Daniel Figueroa-Villar
Jun 4, 2014·Antimicrobial Agents and Chemotherapy·Trupti PandharkarKarl A Werbovetz
Feb 14, 2006·Archiv der Pharmazie·Zeynep Ates-AlagözHakan Göker
Dec 11, 2013·Chembiochem : a European Journal of Chemical Biology·Yun ChaiDavid W Boykin
Mar 22, 2020·Chemistry : a European Journal·Tenuun BayaraaLuke W Guddat
Feb 5, 2021·ACS Infectious Diseases·Ahmed AbdelhameedKarl A Werbovetz
Mar 10, 2009·Journal of Medicinal Chemistry·Svetlana M BakunovaRichard R Tidwell
May 6, 2006·Bioorganic & Medicinal Chemistry·Tesmol G GeorgeKarl A Werbovetz
Aug 7, 2021·Journal of Biomolecular Structure & Dynamics·Kaio Maciel de Santiago-SilvaMarcelle de Lima Ferreira Bispo
Aug 19, 2005·Journal of Medicinal Chemistry·Reem K ArafaDavid W Boykin

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